2. Apoptosis
  3. Photosensitizer
  4. Photosensitizer-10

Photosensitizer-10 是一种可被谷胱甘肽 (GSH) 激活的光敏剂。Photosensitizer-10 在无谷胱甘肽存在时仅表现出极低的光活性，与谷胱甘肽反应后会生成一种高活性物质，进而诱导光细胞毒性。Photosensitizer-10 对细胞内谷胱甘肽水平升高的癌细胞表现出选择性光细胞毒性，而对正常细胞无损伤。Photosensitizer-10 可用于癌症相关研究，例如肺癌和皮肤癌。

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Photosensitizer-10

Photosensitizer-10 Chemical Structure

1.  客户无需承担相应的运输费用。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Photosensitizer-10 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Photosensitizer-10 is a glutathione (GSH)-activatable photosensitizer. Photosensitizer-10 shows minimal photoactivity in the absence of glutathione, and generates a highly active species upon reaction with glutathione to induce photo-cytotoxicity. Photosensitizer-10 exhibits selective photo-cytotoxicity toward cancer cells with elevated intracellular glutathione levels while sparing normal cells. Photosensitizer-10 can be used for the research of cancer, such as lung carcinoma and skin carcinoma[1].

体外研究
(In Vitro)

Photosensitizer-10 (Compound 3) (100 μM) 在 470 nm 处的吸光度降低，限制其激发至单线态激发态并抑制光诱导活性氧 (ROS) 的生成[1]。
Photosensitizer-10 (3-100 μM; 2 h) 表现出对 BSA 可忽略的光诱导降解作用[1]。
Photosensitizer-10 (1-10 μM; 24 h) 对过表达谷胱甘肽 (GSH) 的 A549 和 A431 癌细胞表现出选择性光细胞毒性，而对正常 WI-38 成纤维细胞无损伤[1]。
Photosensitizer-10 被 GSH 激活后可释放活性物质 Compound 2[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Photosensitizer-10 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549 human lung carcinoma cells, A431 human squamous carcinoma cells, WI-38 human lung fibroblasts
Concentration: 1, 3, 10 μM
Incubation Time: 15 min (light irradiation); 24 h (post-irradiation incubation)
Result: Exhibited no dark toxicity across all tested cell lines.
Upon light irradiation, induced dose-dependent cytotoxicity in A549 and A431 cancer cells, while WI-38 normal fibroblasts remained largely unaffected.
At 10 μM, reduced cell viability to ~20% in A549 cells and ~15% in A431 cells, but kept viability near 100% in WI-38 cells.
分子量

511.42

Formula

C22H13N3O10S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Photosensitizer-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Photosensitizer-10Photosensitizer10Photosensitizer 10Photosensitizerglutathionereactive oxygen speciescancer cellssinglet oxygennormal cellsWI-38 fibroblastsA549lung carcinomaskin carcinomaA431Inhibitorinhibitorinhibit

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