2. Apoptosis Others
  3. Photosensitizer Drug Derivative
  4. Photosensitizer-8

Photosensitizer-8 (Compound 4) 是一种 2-anthrol 的衍生物，是一种可被碱性磷酸酶 (ALP) 激活的光敏剂。Photosensitizer-8 在 ALP 存在的情况下会发生磷酸酯水解反应，迅速转化为活性光敏剂 2-anthrol。Photosensitizer-8 在光照后对 ALP 过表达的癌细胞 (HeLa、A549、HCT116) 表现出细胞毒性，其 IC50 值分别为 14.3 μM、21.6 μM 和 17.5 μM，而对正常肺成纤维细胞 (WI-38) 则无显著细胞毒性 (IC50 ≥ 30 μM)。Photosensitizer-8 可用于 ALP 过表达相关癌症的光动力疗法研究。

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Photosensitizer-8

Photosensitizer-8 Chemical Structure

CAS No. : 3106369-28-9

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Photosensitizer-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Photosensitizer-8 (Compound 4), 2-anthrol derivative, is an alkaline phosphatase (ALP)-activatable photosensitizer. Photosensitizer-8 undergoes a phosphate ester hydrolysis reaction in the presence of ALP, rapidly converting into the active photosensitizer 2-anthrol. Photosensitizer-8 exhibits cytotoxicity against ALP-overexpressing cancer cells (HeLa, A549, HCT116) after light exposure, with IC50 values of 14.3 μM, 21.6 μM and 17.5 μM, respectively, while showing no significant cytotoxicity against normal lung fibroblasts (WI-38) (IC50 ≥ 30 μM). Photosensitizer-8 can be used in photodynamic therapy research for ALP-overexpression-related cancers[1].

分子量

274.21

Formula

C14H11O4P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Photosensitizer-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Photosensitizer-83106369-28-9Photosensitizer8Photosensitizer 8PhotosensitizerDrug DerivativeDrug derivativeInhibitorinhibitorinhibit

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