2. PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway Epigenetics
  3. PI3K Akt ERK Epigenetic Reader Domain
  4. PI3K/AKT/ERK/CREB activator 1

PI3K/AKT/ERK/CREB activator 1 是一种口服有效的 PI3K/AKT/ERK/CREB 通路激活剂。PI3K/AKT/ERK/CREB activator 1 可维持神经元存活与功能、促进神经元增殖、恢复损伤神经元的活力，并能促进突触形成。PI3K/AKT/ERK/CREB activator 1 可通过降低促炎细胞因子水平减轻神经炎症，在阿尔茨海默症模型可保留突触超微结构并恢复空间记忆。PI3K/AKT/ERK/CREB activator 1 可用于阿尔茨海默病的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

PI3K/AKT/ERK/CREB activator 1

PI3K/AKT/ERK/CREB activator 1 Chemical Structure

CAS No. : 3107309-22-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PI3K/AKT/ERK/CREB activator 1 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/AKT/ERK/CREB activator 1 is an orally active PI3K/AKT/ERK/CREB pathway activator. PI3K/AKT/ERK/CREB activator 1 maintains neuronal survival and function, promotes neuronal proliferation, restores the viability of damaged neurons, and facilitates synapse formation. PI3K/AKT/ERK/CREB activator 1 alleviates neuroinflammation by reducing the levels of pro-inflammatory cytokines, preserves synaptic ultrastructure and restores spatial memory in Alzheimer's disease models. PI3K/AKT/ERK/CREB activator 1 can be used in research related to Alzheimer's disease[1].

体外研究
(In Vitro)

PI3K/AKT/ERK/CREB activator 1 (Compound A18) (60 μM; 48 h) 可强效促进 SH-SY5Y 细胞增殖，在 60 μM 作用 48 h 时使细胞活力提升 29.4%[1]。
PI3K/AKT/ERK/CREB activator 1 (60 μM; 48 h) 可显著挽救 Rotenone (HY-B1756) 损伤的 SH-SY5Y 细胞，在 60 μM、作用 48 h 时可使细胞活力提升 42.5%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/AKT/ERK/CREB activator 1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SH-SY5Y
Concentration: 60 μM
Incubation Time: 48 h
Result: Enhanced SH-SY5Y cell viability by 29.4% compared to the control group, with a statistically significant effect.

Cell Viability Assay[1]

Cell Line: SH-SY5Y (Rotenone-injured)
Concentration: 60 μM
Incubation Time: 48 h (added 4 h after 5 μM Rotenone exposure)
Result: Increased the viability of rotenone-injured SH-SY5Y cells by 42.5% compared to the rotenone-only control group, with a highly statistically significant effect.
药代动力学
(Parmacokinetics)
Species Dose Route T1/2 Vd/F CL/F
Mice[1] 25 mg/kg p.o. 14.40 h 0.00307 mg/L 15.69 L/h/kg
体内研究
(In Vivo)

PI3K/AKT/ERK/CREB activator 1 (Compound A18) (25-100 mg/kg; 灌胃; 每日一次共 23 天) 在 Aβ1-42 诱导的阿尔茨海默病小鼠模型中展现出强效的多模态疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 3-month-old, 28-32 g, SPF, wild-type, Alzheimer's disease model via unilateral intracerebroventricular injection of aggregated Aβ1-42 peptide)[1]
Dosage: 25 mg/kg/day; 50 mg/kg/day; 100 mg/kg/day
Administration: oral gavage; daily; 23 consecutive days
Result: Significantly increased platform crossings and target quadrant occupancy at 25 mg/kg/day, with platform crossing frequency following a dose-dependent trend: 25 mg/kg > 50 mg/kg > 100 mg/kg.
Reduced escape latency and enhanced spatial orientation compared to the Aβ-only group across all treated groups.
Reversed Aβ1-42-induced neurodegeneration, with higher neuronal density in the hippocampal CA1 region compared to the Aβ-only group , and preserved intact synaptic ultrastructure with defined presynaptic membranes and ordered vesicles.
Suppressed Aβ-induced glial activation, reducing Iba-1+ microglial density and GFAP immunofluorescence intensity, and downregulated hippocampal TNF-α and IL-6 mRNA levels by 40-60%.
Increased hippocampal protein levels: CHRM5, phosphorylated PI3K, AKT, ERK, phosphorylated CREB, and synaptophysin.
Facilitated weight recovery in Aβ-injected mice, with the 25 mg/kg group showing the most rapid recovery to levels comparable to the blank control by day 21.
分子量

905.06

Formula

C47H73N2O13P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/AKT/ERK/CREB activator 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/AKT/ERK/CREB activator 13107309-22-5PI3KAktERKEpigenetic Reader DomainPhosphoinositide 3-kinasePKBProtein kinase BExtracellular signal regulated kinasessynaptogenesisPI3K/AKT pathwayAlzheimer's diseaseBeas-2B cellsERK/CREB pathwaySH-SY5Y cellsneuronal proliferationCHO cellsneuronal survivalneuroinflammationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PI3K/AKT/ERK/CREB activator 1
目录号：
HY-181672
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z