2. PI3K/Akt/mTOR Immunology/Inflammation
  3. PI3K Akt NO Synthase COX Interleukin Related
  4. PI3K/AKT-IN-6

PI3K/AKT-IN-6 是一种口服有效的 PI3K/AKT 信号通路抑制剂及抗炎剂。PI3K/AKT-IN-6 可抑制促炎细胞因子 TNF-α 和 IL-6 产生，并下调炎症介质 COX-2 和 iNOS 的表达。PI3K/AKT-IN-6 可改善结肠炎小鼠的相关症状。PI3K/AKT-IN-6 可用于结肠炎等炎症性疾病的研究。

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PI3K/AKT-IN-6

PI3K/AKT-IN-6 Chemical Structure

1.  客户无需承担相应的运输费用。

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     可免费申领三个不同产品的试用装。

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PI3K/AKT-IN-6 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/AKT-IN-6 is an orally effective PI3K/AKT signaling pathway inhibitor and anti-inflammatory agent. PI3K/AKT-IN-6 inhibits the production of pro-inflammatory cytokines TNF-α and IL-6, and downregulates the expression of inflammatory mediators COX-2 and iNOS. PI3K/AKT-IN-6 improves related symptoms in colitis mice. PI3K/AKT-IN-6 can be used for the research of inflammatory diseases such as colitis[1].

IC50 & Target[1]

COX-2

 

IL-6

 

体外研究
(In Vitro)

PI3K/AKT-IN-6 (compound 110) (10 μM) 可抑制 LPS (HY-D1056) 诱导的 RAW 264.7 巨噬细胞中 NO 的生成，且无明显细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/AKT-IN-6 相关抗体:
体内研究
(In Vivo)

PI3K/AKT-IN-6 (20 mg/kg；口服；每日一次；连续 7 天) 可显著改善 DSS (HY-116282C) 诱导的小鼠溃疡性结肠炎，降低疾病活动指数、促炎细胞因子水平、炎症介质表达及 PI3K/AKT 通路的激活水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J treated DSS (22-25 g)[1]
Dosage: 20 mg/kg
Administration: p.o.; daily; 7 days
Result: Reduced mean body weight loss, with body weigh.
Reduced disease activity index (DAI).
Reduced serum TNF-α, IL-6 levels.
Reduced iNOS/GAPDH, COX-2/GAPDH, p-PI3K/PI3K, p-AKT/AKT ratio in colonic tissue.
Reduced inflammatory cell infiltration and improved goblet cell damage in colon tissue.
分子量

499.36

Formula

C23H25Cl2FN2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/AKT-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/AKT-IN-6PI3KAktNO SynthaseCOXInterleukin RelatedPhosphoinositide 3-kinasePKBProtein kinase BNitric oxide synthasesNOSCyclooxygenaseILCOX-2RAW 264.7 macrophagesDSS-induced ulcerative colitis micePI3K/AKT signaling pathwayulcerative colitislipopolysaccharide-induced macrophagesIL-6TNF-αNO productioniNOSInhibitorinhibitorinhibit

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