2. Antibody-drug Conjugate/ADC Related PI3K/Akt/mTOR
  3. ADC Payload PI3K
  4. PI3K/PIKK-IN-1

PI3K/PIKK-IN-1 是一种 PI3K 和 PIKK 抑制剂，可作为抗体-药物偶联物 (ADC) 的有效载荷，用于制备 ADC。PI3K/PIKK-IN-1 可用于乳腺癌、多发性骨髓瘤、伯基特淋巴瘤、弥漫性大 B 细胞淋巴瘤、非小细胞肺癌的相关研究。

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PI3K/PIKK-IN-1

PI3K/PIKK-IN-1 Chemical Structure

CAS No. : 3109464-35-6

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PI3K/PIKK-IN-1 相关抗体

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/PIKK-IN-1 is a PI3K and PIKK inhibitor that serves as a payload for antibody-drug conjugates (ADC) to prepare ADC. PI3K/PIKK-IN-1 is applicable to research related to breast cancer, multiple myeloma, Burkitt lymphoma, diffuse large B-cell lymphoma, and non-small cell lung cancer[1].

体外研究
(In Vitro)

PI3K/PIKK-IN-1 (Compound 1) (0.000051 μM-3 μM; 1 h) 可在体外强效抑制重组人 FRAP1 (mTOR) 激酶活性，IC50 为 3.6 nM[1]。
PI3K/PIKK-IN-1 (0.046-100 nM; 1 h) 可在体外强效抑制重组人源 PIK3CA/PIK3R1 (p110α/p85α) 激酶活性，IC50 为 0.5 nM[1]。
PI3K/PIKK-IN-1 (0.015-250 nM; 6 d) 可在体外强效抑制 MDA-MB-453 和 MDA-MB-468 乳腺癌细胞的增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/PIKK-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-453 breast cancer cell
Concentration: 0.015-250 nM
Incubation Time: 6 days
Result: Inhibited MDA-MB-453 breast cancer cell proliferation with an IC50 of 0.23 nM.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-468 breast cancer cell
Concentration: 0.015-250 nM
Incubation Time: 6 days
Result: Inhibited MDA-MB-468 breast cancer cell proliferation with an IC50 of 0.39 nM.
分子量

479.55

Formula

C23H25N7O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/PIKK-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/PIKK-IN-13109464-35-6ADC PayloadPI3KADC CytotoxinPhosphoinositide 3-kinasemultiple myelomadiffuse large b-cell lymphomaPIK3CA/PIK3R1 (p110α/p85α)breast cancerMDA-MB-453HCC1954non-small cell lung cancerburkitt lymphomaFRAP1 (mTOR)MDA-MB-468Inhibitorinhibitorinhibit

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目录号：
HY-181833
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