2. JAK/STAT Signaling
  3. Pim
  4. PIM-IN-4

PIM-IN-4 是一种 Pim 激酶抑制剂，对 Pim-1、2、3 的 Ki 分别为 2、3、0.5 nM。PIM-IN-4 可阻断促凋亡蛋白 Bad 的磷酸化过程。PIM-IN-4 可抑制白血病细胞的生长。PIM-IN-4 可用于白血病相关研究。

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PIM-IN-4

PIM-IN-4 Chemical Structure

CAS No. : 1036380-87-6

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PIM-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Pim 亚型特异性产品:

查看所有亚型
PIM1 PIM2 PIM3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PIM-IN-4 is a Pim kinase inhibitor with Ki values of 2, 3, and 0.5 nM against Pim-1, 2, 3, respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad. PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research[1].

体外研究
(In Vitro)

PIM-IN-4 (Compound 14j) (0.01-30 μM; 48 h) 可抑制人白血病细胞 K562 和 MV4-11 的增殖，其 EC50 值分别为 1.7 μM 和 2.4 μM[1]。
PIM-IN-4 (4 h) 可抑制 K562 人白血病细胞中 Bad 蛋白的丝氨酸-112 位点磷酸化，其 EC50 值为 0.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PIM-IN-4 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route AUC0-∞ Cmax Tmax Bioavailability CL Vd T1/2
Mice[1] 3 mg/kg i.v. 1.10 μM·h / / / 7.80 L/h/kg 23.5 L/kg 2.10 h
Mice[1] 10 mg/kg p.o. 2.80 μM·h 0.52 μM 0.3 h 76 % / / /
分子量

351.42

Formula

C19H17N3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PIM-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIM-IN-41036380-87-6PimPim kinasesBadPim-1MV4-11Pim-2Pim kinaseCD-1 miceserine/threonine kinaseK562leukemia cellsPim-3Inhibitorinhibitorinhibit

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目录号：
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