2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. PI4K Hedgehog
  4. Pipinib

Pipinib 是一种 ATP 竞争性和选择性磷脂酰肌醇 4-激酶 IIIb (PI4KB) 抑制剂，其 IC50 为 2.2 μM。Pipinib 可降低细胞内 PI4P 水平。Pipinib 可抑制 GLI 介导的转录、Hedgehog 靶基因的表达，并阻碍 Smoothened 向纤毛的转运。Pipinib 可用于基底细胞癌和髓母细胞瘤的研究。

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Pipinib

Pipinib Chemical Structure

CAS No. : 2380013-55-6

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Pipinib 相关抗体

Top Publications Citing Use of Products

查看 PI4K 亚型特异性产品:

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PI4KIIIβ PI4KIIIα PI4K PI4KII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC50 of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma[1].

体外研究
(In Vitro)

Pipinib (0.001-10 μM; 96 h) 可抑制 Purmorphamine (HY-15108) 诱导的 C3H10T1/2 细胞成骨作用，其 IC50 为 0.6 μM[1]。
Pipinib (0.01-100 μM; 48 h) 可在 Shh-LIGHT2 细胞中抑制 GLI 介导的转录，其 IC50 为 1.7 μM[1]。
Pipinib (0.01-10 μM; 48 h) 可降低 Purmorphamine 诱导的 NIH/3T3 细胞中 Ptch1 和 Gli1 的表达，其 IC50 值分别为 3.1 μM 和 4.1 μM[1]。
Pipinib (5 μM; 48 h) 可降低 NIH/3T3 细胞内的 PI4P 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pipinib 相关抗体:

Cell Differentiation Assay[1]

Cell Line: C3H10T1/2 mesenchymal progenitor cells
Concentration: 0.001, 0.01, 0.1, 1, 10 μM
Incubation Time: 96 h
Result: Potently inhibited Purmorphamine-induced osteogenesis, with an IC50 of 0.6 μM.
分子量

342.42

Formula

C17H18N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pipinib 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pipinib2380013-55-6PI4KHedgehogPhosphatidylinositol 4 kinasesPI4 kinasesC3H10T1/2 cellsmedulloblastomaHedgehog pathwayGLI-mediated transcriptionbasal cell carcinomaPI4KBphosphatidylinositol 4-kinase IIIbShh-LIGHT2 cellsphosphatidylinositol 4-phosphatePI4PInhibitorinhibitorinhibit

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