2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB MAPK/ERK Pathway
  3. Apoptosis Reactive Oxygen Species (ROS) JNK p38 MAPK MMP
  4. Pipoxolan hydrochloride

Pipoxolan hydrochloride 是一种解痉剂。Pipoxolan hydrochloride 可诱导凋亡 (Apoptosis)，增加细胞内 ROS 水平。Pipoxolan hydrochloride 可下调 JNK 和 p38 的磷酸化水平，进而下调 MMP-2 和 MMP-9。Pipoxolan hydrochloride 可缓解消化系统、泌尿系统和妇科的平滑肌痉挛。Pipoxolan hydrochloride 还对白血病、口腔鳞状细胞癌和肺腺癌发挥抗癌活性。

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Pipoxolan hydrochloride

Pipoxolan hydrochloride Chemical Structure

CAS No. : 18174-58-8

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Pipoxolan hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

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生物活性

Pipoxolan hydrochloride is an anti-spasmotic agent. Pipoxolan hydrochloride induces Apoptosis, increases intracellular ROS. Pipoxolan hydrochloride down-regulates phosphorylation JNK and p38, and then, MMP-2 and -9. Pipoxolan hydrochloride relieves smooth muscle spasms in the digestive, urinary, and gynecological systems. Pipoxolan hydrochloride also exhibits anticancer activity against leukemia, oral squamous cell carcinoma, and lung adenocarcinoma[1][2][3][4].

IC50 & Target[3]

MMP-9

 

MMP-2

 

分子量

387.90

Formula

C22H26ClNO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pipoxolan hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pipoxolan18174-58-8ApoptosisReactive Oxygen Species (ROS)JNKp38 MAPKMMPc-Jun N-terminal kinaseMatrix metalloproteinasesanti-spasmoticanticancerleukemiaoral squamous cell carcinomaand lung adenocarcinomaInhibitorinhibitorinhibit

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