2. Neuronal Signaling Stem Cell/Wnt PI3K/Akt/mTOR
  3. Cholinesterase (ChE) GSK-3
  4. PJ17

PJ17 是一种强效的 AChE 和 GSK-3β 双靶点抑制剂，其 IC50 值分别为 8.84 μM 和 4.19 μM。PJ17 在原代小脑颗粒神经元培养体系中无显著神经毒性。PJ17 可作为多靶点药物设计的模板。PJ17 可用于阿尔茨海默病的研究。

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PJ17

PJ17 Chemical Structure

CAS No. : 2248983-31-3

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PJ17 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

查看 GSK-3 亚型特异性产品:

查看所有亚型
GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease[1].

IC50 & Target[1]

AChE

8.84 μM (IC50)

GSK-3β

4.19 μM (IC50)

体外研究
(In Vitro)

PJ17 (30-100 μM) 可强效抑制 AChE，其 IC50 为 8.84 μM[1]。
PJ17 (10 μM) 可强效抑制人源重组 GSK-3β，其 IC50 为 4.19 μM，在 10 μM 时抑制率达 85.95%[1]。
PJ17 (2.5-50 μM; 24-48 h) 在浓度高达 50 μM 时不会诱导原代 CGN 培养物产生神经毒性，且在 10-50 μM 时可提高细胞存活率[1]。
PJ17 (2.5-50 μM; 1-24 h pretreatment) 在浓度高达 50 μM 时，对 Rotenone (HY-B1756) 诱导的原代小脑颗粒神经元 (CGN) 培养物毒性未表现出显著的神经保护活性[1]。
PJ17 对大鼠 MAO-A、MAO-B 及人重组 BACE-1 无显著抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PJ17 相关抗体:

Cell Viability Assay[1]

Cell Line: Primary cerebellar granule neurons (CGNs) cultures
Concentration: 2.5, 5, 10, 25, 50 μM
Incubation Time: 24 h, 48 h
Result: Showed no significant decrease in cell viability after 24 or 48 h of incubation at any tested concentration.
Increased cell viability at 10-50 μM.

Cell Viability Assay[1]

Cell Line: Primary cerebellar granule neurons (CGNs) cultures
Concentration: 2.5, 5, 10, 25, 50 μM
Incubation Time: 1 h pretreatment, 24 h pretreatment; 24 h Rotenone (HY-B1756) exposure
Result: Did not significantly prevent rotenone-induced cell viability reduction.
分子量

300.29

Formula

C15H13FN4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PJ17 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PJ172248983-31-3PJ 17PJ-17Cholinesterase (ChE)GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3nAChR7primary cerebellar granule neuron culturesacetylcholinesterasehuman glycogen synthase kinase 3 betaelectric eel acetylcholinesteraseglycogen synthase kinase 3 betaBOSC-23 cellsAlzheimer's diseaseElectrophorus electricusGSK-3βInhibitorinhibitorinhibit

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HY-181811
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