1. 疾病领域
  2. 癌症 泌尿生殖系统疾病
  3. 膀胱癌 泌尿生殖系统癌症
  4. Plenolin

Plenolin 是一种抗癌剂。Plenolin 对人表皮样癌细胞有抑制活性。Plenolin 在啮齿动物模型中对腹水癌肉瘤和淋巴细胞白血病表现出体内抗肿瘤活性。Plenolin 可用于腹水瘤、白血病的相关研究。

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Plenolin

Plenolin Chemical Structure

CAS No. : 34257-95-9

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Plenolin is an anticancer agent. Plenolin exhibits inhibitory activity against human epidermoid carcinoma cells. Plenolin shows in vivo antitumor activity against ascites carcinosarcoma and lymphocytic leukemia in rodent models. Plenolin can be used for research related to ascites tumors and leukemia[1].

体外研究
(In Vitro)

Plenolin (Compound 3) 对 H.Ep.-2 细胞的细胞毒性 ED50 为 0.814 μg/mL[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Plenolin (33.3 mg/kg;腹腔注射;每日;7 天) 可对 CF1 雄性小鼠的艾氏腹水癌生长产生 100.0%的抑制作用,完全抑制腹水积聚,且经处理的小鼠在第 7 天的存活率达 100%[1]
Plenolin (2.5 mg/kg;腹腔注射) 对荷 Walker 256 腹水癌肉瘤的雄性大鼠的平均存活天数的 T/C 值为 207[1]
Plenolin (25 mg/kg;腹腔注射) 在接种 P388 白血病的 DBA/2 雄性小鼠中,可使平均存活天数的 T/C 值达到 134[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CF1 (male, ~30 g, implanted with 106 Ehrlich ascites carcinoma cells)[1]
Dosage: 33.3 mg/kg/day
Administration: i.p.; daily
Result: Achieved 100.0% inhibition of tumor growth.
Reduced ascites-crit to 0.
Reduced total ascites fluid volume to 0.0 mL.
Ensured 100% survival of 5 treated mice to day 7.
分子量

264.32

Formula

C15H20O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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