Poly(acrylic acid) (MW 250000) 

Poly(acrylic acid) (MW 250000) is a synthetic cationic electrolyte containing abundant carboxyl groups (-COOH), which exhibits excellent water absorption and retention properties and is often cross-linked to form hydrogels. Poly(acrylic acid) (with a molecular weight of 250,000). Poly(acrylic acid) (MW 250000) can be used as a non-collagenous analog in the biomimetic mineralization research of type I collagen. Poly(acrylic acid) (MW 250000) has pH responsiveness and biocompatibility and is often used as a drug carrier, surface modifier and functional material^[1][2][3].

Poly(acrylic acid) 引导 Hydroxyapatite (HY-D0835A) 在胶原蛋白原纤维内部有序沉积，从而实现类似天然骨骼和牙本质的原纤维内矿化。低分子量 (如2 kDa) 链较短，更容易渗透进入胶原原纤维内部，从而实现原纤维内矿化 (IM)；高分子量 (如450 kDa) 链较长，主要存在于原纤维外部，更易引导矿物质在原纤维表面沉积，导致原纤维外矿化 (EM)^[1]。
Poly(acrylic acid) (MW 150000) 用于构建一种用于透皮给药的新型载体 (PAA-MoS₂ NPs)，具有更高的稳定性和更强的载药能力^[2]。
Poly(acrylic acid) 作为共聚物的主链，用于接枝靶向分子甘露糖 (Mannose)，形成甘露糖接枝的 PAA 共聚物 (man-g-PAA)。man-g-PAA 被用作介孔二氧化硅纳米颗粒 (MSNs) 的表面涂层，以改善其生物相容性并实现 pH 响应性药物释放^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

250000 (Average)

(C₃H₄O₂)x

9003-01-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen L, et al. Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review. Macromol Rapid Commun. 2023 May;44(9):e2200827.  [Content Brief]

  [2]. Zhang K, et al. Poly(Acrylic Acid)-Modified MoS2 Nanoparticle-Based Transdermal Delivery of Atenolol. Int J Nanomedicine. 2020 Aug 4;15:5517-5526.  [Content Brief]

  [3]. Lee H, et al. Mannosylated poly(acrylic acid)-coated mesoporous silica nanoparticles for anticancer therapy. J Control Release. 2022 Sep;349:241-253.  [Content Brief]