2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPARγ agonist-23

PPARγ agonist-23 (Compound 9) 是一种具有口服活性的 PPARγ 激动剂，EC50 为 0.32 μM。PPARγ agonist-23 可改善肝脏甘油三酯水平，降低脂肪变性和肝细胞气球样变评分，并降低非酒精性脂肪性肝炎 (NASH) 的总活动度评分。PPARγ agonist-23 可用于非酒精性脂肪性肝炎的研究。

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PPARγ agonist-23

PPARγ agonist-23 Chemical Structure

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PPARγ agonist-23 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

查看所有亚型
PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPARγ agonist-23 (Compound 9) is an orally active PPARγ agonist with an EC50 of 0.32 μM. PPARγ agonist-23 improves hepatic triglyceride levels, reduces scores of steatosis and hepatocellular ballooning, and decreases the total activity score of non-alcoholic steatohepatitis (NASH). PPARγ agonist-23 can be used for the research of non-alcoholic steatohepatitis[1].

产品应用

1. 该化合物可作为示踪剂。
2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
IC50 & Target[1]

PPARγ

0.32 μM (EC50)

体外研究
(In Vitro)

PPARγ agonist-23 可在 HEK293 细胞中激活 PPARγ，其 EC50 为 0.32 ± 0.04 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PPARγ agonist-23 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Cmax AUC0-24 Tmax T1/2
Rat[1] 15 mg/kg p.o. 1693 ± 339 ng/mL 8711 ± 871 ng·h/mL 1.60 ± 0.13 h 2.25 ± 0.45 h
体内研究
(In Vivo)

PPARγ agonist-23 (25 mg/kg，口服，每日一次) 可显著改善非酒精性脂肪性肝炎 (NASH) 小鼠模型的病症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male; NASH induced via high-fat diet and streptozotocin)[1]
Dosage: 25 mg/kg
Administration: p.o.; daily
Result: Significantly reduced liver triglyceride levels.
Reduced steatosis scores by 36.8% (P < 0.05) and ballooning scores by 49% (P < 0.05).
Produced a statistically significant improvement in the overall Non-alcoholic Fatty Liver Disease Activity Score (NAS) (P < 0.05).
Showed no significant difference in weight gain compared to vehicle group.
分子量

526.61

Formula

C28H18D7NO7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPARγ agonist-23 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARγ agonist-23PPARγ agonist23PPARγ agonist 23PPARPeroxisome proliferator-activated receptorsliver triglyceridehepatocellular ballooningHEK293 cellsmouse model of NASHnonalcoholic steatohepatitissteatosisperoxisome proliferator-activated receptor gammaTZD derivativesInhibitorinhibitorinhibit

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产品名称：
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目录号：
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