2. Apoptosis Cell Cycle/DNA Damage GPCR/G Protein
  3. Bcl-2 Family DNA/RNA Synthesis Apoptosis Prostaglandin Receptor
  4. Proquinazid

Proquinazid 是一种 Bcl-2 和 PCNA 调节剂、氧化应激诱导剂、基因毒素与细胞凋亡诱导剂。Proquinazid 可造成 DNA 损伤，也可通过调控促凋亡和抗凋亡蛋白触发细胞凋亡。

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Proquinazid

Proquinazid Chemical Structure

CAS No. : 189278-12-4

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Other Forms of Proquinazid:

Proquinazid 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

查看 DNA/RNA Synthesis 亚型特异性产品:

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Proquinazid is a Bcl-2 and PCNA modulator, oxidative stress inducer, genotoxin and apoptosis inducer. Proquinazid causes DNA damage and also triggers apoptosis by regulating pro-apoptotic and anti-apoptotic proteins[1].

体内研究
(In Vivo)

Proquinazid (1-8 mg/kg bw/天；口服；每日；连续 28 天) 可通过氧化应激、遗传毒性损伤和细胞凋亡，在雄性 Wistar 大鼠中诱导剂量依赖性的肝毒性和肾毒性，即使在 1 mg/kg bw/天的剂量下也可观察到显著效应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (male, 8 weeks old, 170 ± 21 g)[1]
Dosage: 1 mg/kg bw/day; 2 mg/kg bw/day; 4 mg/kg bw/day; 8 mg/kg bw/day
Administration: p.o.; daily; 28 days
Result: Increased body weight gain significantly.
Increased serum creatinine to 104.06 μmol/L (8 mg/kg).
Increased uric acid to 97.16 μmol/L (8 mg/kg).
Increased urea to 16.86 mmol/L (8 mg/kg).
Increased AST to136 UI/L (8 mg/kg).
Increased ALT 47.66 UI/L (8 mg/kg).
Increased ALP to 203.66 UI/L (8 mg/kg).
Increased LDH to 579 UI/L (8 mg/kg).
Increased SOD, CAT, GST activities at 1 mg/kg and 2 mg/kg, then decreased at 4 mg/kg and 8 mg/kg in liver and kidney.
Increased GPx activity in a dose-dependent manner across all doses in liver and kidney.
Increased renal MDA to 32.92 μmol/mg protein (8 mg/kg).
Increased hepatic MDA to 62.69 μmol/mg protein (8 mg/kg).
Increased renal protein carbonyl to 208.13 nmol/mg protein (8 mg/kg).
Increased hepatic protein carbonyl to 295.61 nmol/mg protein (8 mg/kg).
Increased TUNEL-positive apoptotic cells in a dose-dependent manner in liver and kidney.
Induced dose-dependent downregulation of Bcl-2 and PCNA, and upregulation of Bax, p53, and caspase-3, with increased Bax/Bcl-2 ratio in liver and kidney.
分子量

372.21

Formula

C14H17IN2O2
CAS 号
中文名称

丙氧喹啉
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Proquinazid 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proquinazid189278-12-4丙氧喹啉Bcl-2 FamilyDNA/RNA SynthesisApoptosisProstaglandin ReceptorBaxBcl-2malondialdehydep53PCNAcatalaseglutathione S-transferasesuperoxide dismutasecaspase-3male Wistar ratsInhibitorinhibitorinhibit

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目录号：
HY-117171
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