2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs Aurora Kinase
  4. PROTAC AURKA degrader 2

PROTAC AURKA degrader 2 (compound D) 是一种高效且选择性的 PROTAC AURKA 降解剂，IC50 为 3.58 nM。PROTAC AURKA degrader 2 对 AURKA 的选择性比 AURKB (IC50 = 77.2 nM) 高 21.6 倍 。PROTAC AURKA degrader 2 特异性地消耗有丝分裂纺锤体上的 AURKA。
(粉色: Aurora Kinase 和 Aurora A 配体 (HY-10971)；蓝色: Ligands for E3 Ligase 和 Cereblon 配体 (HY-41547)；黑色: 连接子 (HY-W008352))。

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PROTAC AURKA degrader 2

PROTAC AURKA degrader 2 Chemical Structure

CAS No. : 3093582-13-6

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PROTAC AURKA degrader 2 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Aurora Kinase 亚型特异性产品:

查看所有亚型
Aurora Kinase Aurora A Aurora B Aurora C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC AURKA degrader 2 (compound D) is a potent and selective PROTAC AURKA degrader with an IC50 of 3.58 nM. PROTAC AURKA degrader 2 exhibits 21.6-fold selectivity for AURKA over AURKB (IC50 = 77.2 nM). PROTAC AURKA degrader 2 specifically depletes AURKA on the mitotic spindle[1]. (Pink: Aurora Kinase and Aurora A ligand (HY-10971); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-41547); Black: linker (HY-W008352)).

IC50 & Target[1]

Aurora A

3.58 nM (IC50)

Aurora B

77.2 nM (IC50)

分子量

993.43

Formula

C50H50ClFN8O11
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC AURKA degrader 2 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC AURKA degrader 23093582-13-6PROTAC AURKA degrader2PROTAC AURKA degrader-2PROTACsAurora KinaseAURKAAURKBmitotic spindleInhibitorinhibitorinhibit

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目录号：
HY-180132
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