2. PROTAC Metabolic Enzyme/Protease Anti-infection
  3. PROTACs Ligands for E3 Ligase Dihydrofolate reductase (DHFR) Parasite
  4. PROTAC DHFR Degrader-1

PROTAC DHFR Degrader-1 是一种靶向恶性疟原虫 (Plasmodium falciparum) DHFR-TS 的 PROTAC 降解剂，其 Ki 值为 2.01 nM。PROTAC DHFR Degrader-1 对人源 DHFR 无抑制活性，且可抑制恶性疟原虫的生长。PROTAC DHFR Degrader-1 可用于恶性疟原虫和疟疾相关研究。
(粉色: Dihydrofolate reductase (DHFR) 配体 (HY-153007)；蓝色: MDM-2/p53 配体 (HY-15676)；黑色: 连接子)。

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PROTAC DHFR Degrader-1

PROTAC DHFR Degrader-1 Chemical Structure

CAS No. : 3077918-47-6

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PROTAC DHFR Degrader-1 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Ligands for E3 Ligase 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC DHFR Degrader-1 is a selective PROTAC degrader targeting Plasmodium falciparum DHFR-TS with a Ki of 2.01 nM. PROTAC DHFR Degrader-1 exhibits no inhibitory activity against human DHFR and suppresses the growth of Plasmodium falciparum. PROTAC DHFR Degrader-1 can be used for the research of Plasmodium falciparum and malaria[1]. (Pink: Dihydrofolate reductase (DHFR) ligand (HY-153007); Blue: MDM-2/p53 ligand (HY-15676); Black: linker).

IC50 & Target[1]

Plasmodium

2.01 nM (Ki)

MDM2

 

体外研究
(In Vitro)

PROTAC DHFR Degrader-1 (IId) 可强效抑制野生型恶性疟原虫二氢叶酸还原酶 (DHFR-TS)，平均 Ki 为 2.01 nM，且在浓度高达 100,000 nM 时不会抑制人源二氢叶酸还原酶[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC DHFR Degrader-1 相关抗体:
分子量

1061.99

Formula

C53H60Cl2F2N8O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC DHFR Degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC DHFR Degrader-13077918-47-6PROTAC DHFR Degrader1PROTAC DHFR Degrader 1PROTACsLigands for E3 LigaseDihydrofolate reductase (DHFR)ParasiteE3 ligase-recruiting Moietydihydrofolate reductasePlasmodium falciparummalariahuman dihydrofolate reductaseInhibitorinhibitorinhibit

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目录号：
HY-181813
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