2. Protein Tyrosine Kinase/RTK
  3. RET
  4. PROTAC HyTTD Degrader-1

PROTAC HyTTD Degrader-1 (Compound B2) 是一种靶向 RET 的疏水标签连接降解剂 (HyTTD)，同时也是 CCDC6-RET 融合蛋白降解剂。PROTAC HyTTD Degrader-1 可通过泛素-蛋白酶体通路诱导 CCDC6-RET 融合蛋白降解。PROTAC HyTTD Degrader-1 可用于 RET 驱动型癌症的研究。
(粉色: FLT3 和 RET 配体 (HY-149539)；蓝色: Others 配体 (HY-W013021)；黑色: 连接子 (HY-76667))。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PROTAC HyTTD Degrader-1

PROTAC HyTTD Degrader-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PROTAC HyTTD Degrader-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC HyTTD Degrader-1 (Compound B2) is a hydrophobic tag tethered degrader (HyTTD) targeting RET, as well as a degrader of the CCDC6-RET fusion protein. PROTAC HyTTD Degrader-1 induces the degradation of the CCDC6-RET fusion protein via the ubiquitin-proteasome pathway. PROTAC HyTTD Degrader-1 is applicable to the research of RET-driven cancers[1]. (Pink: FLT3 and RET ligand (HY-149539); Blue: Others ligand (HY-W013021); Black: linker (HY-76667)).

体外研究
(In Vitro)

PROTAC HyTTD Degrader-1 (1-10 μM; 48 h) 在 TPC-1 细胞中，于 10 μM 作用 48 h 时可使 CCDC6-RET 融合蛋白的降解率达到 91.4%，而在 1 μM 作用 48 h 时降解率不足 20%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC HyTTD Degrader-1 相关抗体:
分子量

584.68

Formula

C33H37FN6O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC HyTTD Degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC HyTTD Degrader-1PROTAC HyTTD Degrader1PROTAC HyTTD Degrader 1RETGFP-CCDC6-RETubiquitin-proteasome pathwayRET-driven cancersCCDC6-RET fusion proteinTPC-1 cellsHEK293T cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PROTAC HyTTD Degrader-1
目录号：
HY-181895
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z