2. PROTAC Cell Cycle/DNA Damage Apoptosis
  3. PROTACs Polo-like Kinase (PLK) Apoptosis
  4. PROTAC PLK1 Degrader-2

PROTAC PLK1 Degrader-2 (Compound NC1) 是一种 PLK1 PROTAC 降解剂，其 Kd 为 6.06 μM。PROTAC PLK1 Degrader-2 显著抑制 HeLa 细胞增殖，诱导细胞周期阻滞和凋亡 (apoptosis)。PROTAC PLK1 Degrader-2 在 HeLa 细胞异种移植瘤小鼠模型中具有显著抗肿瘤活性。PROTAC PLK1 Degrader-2 可用于研究宫颈癌。
(粉色: PLK1 配体 (HY-180990)；蓝色: Ligands for E3 Ligase 配体 (HY-P11631)；黑色: 连接子 (HY-B0236))。

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Custom Peptide Synthesis

PROTAC PLK1 Degrader-2

PROTAC PLK1 Degrader-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

PROTAC PLK1 Degrader-2 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Polo-like Kinase (PLK) 亚型特异性产品:

查看所有亚型
PLK1 PLK2 PLK3 PLK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC PLK1 Degrader-2 (Compound NC1) is a PLK1 PROTAC degrader with an Kd of 6.06 μM. PROTAC PLK1 Degrader-2 significantly inhibits the proliferation of HeLa cells, induces cell cycle arrest and apoptosis. PROTAC PLK1 Degrader-2 exhibits significant anti-tumor activity in a HeLa cell xenograft tumor mouse model. PROTAC PLK1 Degrader-2 can be used for the study of cervical cancer. (Pink: PLK1 ligand (HY-180990); Blue: Ligands for E3 Ligase ligand (HY-P11631); Black: linker (HY-B0236)).

IC50 & Target[1]

PLK1

6.06 μM (IC50)

分子量

2794.27

Formula

C115H214N57O23P
Sequence

Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-{Ahx}-Pro-Leu-{His(n-octylphenyl )}-Ser-{pThr}-NH2
Sequence Shortening

RRRRRRRRRRRR-{Ahx}-PL-{His(n-octylphenyl )}-S-{pThr}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC PLK1 Degrader-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC PLK1 Degrader-2PROTACsPolo-like Kinase (PLK)ApoptosisPROTACPLK1N-end rule pathwaycervical cancerprotein degradationUBR E3 ligaseapoptosisanticancer therapyInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-180989
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