2. PROTAC Stem Cell/Wnt Apoptosis
  3. PROTACs YAP IAP
  4. PROTAC TEAD1/IAP degrader-2

PROTAC TEAD1/IAP degrader-2 是一种 IAP 招募型 TEAD1 PROTAC 降解剂，其在 NCI-H2052 细胞中对 TEAD1 的 DC50 为 170 nM。PROTAC TEAD1/IAP degrader-2 在 Hippo 通路依赖的间皮瘤细胞中表现出中等强度的抗增殖活性。PROTAC TEAD1/IAP degrader-2 能抑制 CTGF 的表达，但效果弱于 TEAD 抑制剂 VT-107 (HY-134957)。PROTAC TEAD1/IAP degrader-2 可用于间皮瘤的相关研究。

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PROTAC TEAD1/IAP degrader-2

PROTAC TEAD1/IAP degrader-2 Chemical Structure

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PROTAC TEAD1/IAP degrader-2 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 YAP 亚型特异性产品:

查看所有亚型
YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

查看 IAP 亚型特异性产品:

查看所有亚型
cIAP cIAP-1 cIAP-2 XIAP

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC TEAD1/IAP degrader-2 is an IAP-harnessing TEAD1 PROTAC degrader, with a DC50 of 170 nM against TEAD1 in NCI-H2052 cells. PROTAC TEAD1/IAP degrader-2 exhibits moderate antiproliferative activity in Hippo pathway-dependent mesothelioma cells. PROTAC TEAD1/IAP degrader-2 inhibits the expression of CTGF, but with a weaker effect than the TEAD inhibitor VT-107 (HY-134957). PROTAC TEAD1/IAP degrader-2 can be used in mesothelioma-related research[1].

IC50 & Target[1]

TEAD1

170 nM (DC50)

cIAP

 

体外研究
(In Vitro)

PROTAC TEAD1/IAP degrader-2 (Compound A531) (1 nM-10000 nM; 144 h) 可抑制 Hippo 通路依赖性间皮瘤细胞 (ZL55、NCI-H226、NCI-H2052) 及 Hippo 通路非依赖性 NCI-H520 细胞的增殖；其中在 NCI-H226 细胞中的活性最强 (IC50 = 310 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC TEAD1/IAP degrader-2 相关抗体:
分子量

912.00

Formula

C48H44F3N11O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC TEAD1/IAP degrader-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC TEAD1/IAP degrader-2PROTACsYAPIAPYes-associated proteinCCN2NCI-H2052NCI-H226CTGFHippo pathwayXIAPcIAP1TEAD1CCN1mesothelioma cellsInhibitorinhibitorinhibit

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产品名称：
PROTAC TEAD1/IAP degrader-2
目录号：
HY-181537
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