2. PROTAC Epigenetics
  3. PROTACs WDR5
  4. PROTAC WDR5 degrader 2

PROTAC WDR5 degrader 2 是一种 WDR5 PROTAC 降解剂。PROTAC WDR5 degrader 2 可通过与 WDR5 和 E3 连接酶形成三元复合物，经泛素-蛋白酶体系统诱导 WDR5 降解。PROTAC WDR5 degrader 2 可用于白血病相关研究。
(粉色: WDR5 配体 (HY-181973)；蓝色: VHL 配体 (HY-125845)；黑色: 连接子 (HY-N0216))。

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PROTAC WDR5 degrader 2

PROTAC WDR5 degrader 2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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PROTAC WDR5 degrader 2 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC WDR5 degrader 2 is a WDR5 PROTAC degrader. PROTAC WDR5 degrader 2 induces WDR5 degradation via the ubiquitin-proteasome system by forming a ternary complex with WDR5 and an E3 ligase. PROTAC WDR5 degrader 2 can be used in leukemia-related research[1]. (Pink: WDR5 ligand (HY-181973); Blue: VHL ligand (HY-125845); Black: linker (HY-N0216)).

体外研究
(In Vitro)

PROTAC WDR5 degrader 2 (Compound A11 + X37) (1 μM; 6 h-12 h) 可在分别以 1 μM 处理 6 h 或 12 h 时，显著降解 MV4-11WDR5‑HiBiT 和 MV4-11WDR5‑Nluc (Kless) 细胞中的 WDR5[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC WDR5 degrader 2 相关抗体:
分子量

1228.36

Formula

C63H69F4N13O7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC WDR5 degrader 2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC WDR5 degrader 2PROTACsWDR5WD repeat protein-5WD40 repeat domain protein 5ubiquitin-proteasome systemE3 ligaseMV4-11WDR5?Nluc(Kless)ternary complexMV4-11WDR5?HiBiTleukemiaInhibitorinhibitorinhibit

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产品名称：
PROTAC WDR5 degrader 2
目录号：
HY-181972
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