2. PSMA ligand 2

PSMA ligand 2 是一种带有谷氨酸-尿素-赖氨酸 (GUL) 结构域的前列腺特异性膜抗原 (PSMA) 配体。PSMA ligand 2 可被 68Ga、177Lu 等放射性核素高效标记，并能特异性结合 PSMA 阳性肿瘤细胞。PSMA ligand 2 可通过 PET 或 SPECT 成像技术用于表达 PSMA 的肿瘤或细胞的成像研究。PSMA ligand 2 可用于前列腺癌的相关研究。

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PSMA ligand 2

PSMA ligand 2 Chemical Structure

CAS No. : 2576410-20-1

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PSMA ligand 2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSMA ligand 2 is a prostate specific membrane antigen (PSMA) ligand with a glutamate-urea-lysine (GUL) moiety. PSMA ligand 2 can be efficiently labeled with radioactive nuclides such as 68Ga and 177Lu and specifically binds to PSMA-positive tumor cells. PSMA ligand 2 can be used for imaging of PSMA-expressing tumors or cells via PET or SPECT imaging. PSMA ligand 2 can be used for the research of prostate cancer[1].

体外研究
(In Vitro)

PSMA ligand 2 (Compound PSMA‑R2) (10 μg/mL; 30-120 min) 在人血浆中表现出良好的稳定性，在 37°C、10 μg/mL 条件下孵育 2 小时后仍保留 85%的回收率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PSMA ligand 2 相关抗体:
体内研究
(In Vivo)

PSMA ligand 2 (68Ga‑PSMA‑R2) (4.44-5.55 MBq；静脉注射；单剂量) 在健康 CD-1 小鼠中表现出肾脏排泄特征，注射后 4 小时内初始膀胱摄取量较高，而肾脏及全身各器官的摄取量逐渐降低[1]。
PSMA ligand 2 (68Ga‑PSMA‑R2) (4.5 MBq；静脉注射；单次给药) 在注射后 1 小时对无胸腺裸鼠的 PSMA 阳性前列腺肿瘤表现出高摄取，肿瘤与肾脏的比值为 5[1]。
PSMA ligand 2 (111 MBq；静脉注射；单次给药) 在裸鼠中可显著缩小 PSMA 阳性前列腺肿瘤体积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing PC3-PIP[1]
Dosage: 111 MBq
Administration: i.v.; single dose
Result: Reduced tumor volume.
分子量

987.89

Formula

C41H63BrN8O15
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PSMA ligand 2 相关分类

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Keywords:

PSMA ligand 22576410-20-1PSMA ligand2PSMA ligand-2prostate specific membrane antigenPSMA-expressing tumorsglutamate-urea-lysineprostate cancerathymic nude micehuman plasmaPSMA-positive prostate tumorsCD-1 miceInhibitorinhibitorinhibit

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