2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. PTER-IN-1

PTER-IN-1 是一种 PTER 选择性抑制剂，对 HDACs 有选择性。PTER-IN-1 可提高瘦小鼠和肥胖小鼠体内的 N-乙酰牛磺酸水平，降低肥胖小鼠的食物摄入量。PTER-IN-1 可用于肥胖症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

PTER-IN-1

PTER-IN-1 Chemical Structure

CAS No. : 3114432-21-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PTER-IN-1 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PTER-IN-1 is a selective inhibitor of PTER with selectivity towards HDACs. PTER-IN-1 increases the level of N-acetyltaurine in both lean and obese mice, and reduces food intake in obese mice. PTER-IN-1 can be used in the research of obesity[1].

体外研究
(In Vitro)

PTER-IN-1 (Compound 41) (1 h) 可强效且选择性地抑制重组小鼠 PTER 介导的 N-乙酰牛磺酸水解，对 HDAC 酶的选择性超过 250 倍[1]。
PTER-IN-1 对 HDACs 1-11 和 SIRTs 1-4 仅表现出微弱的抑制活性，对 PTER 具有高选择性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PTER-IN-1 相关抗体:
体内研究
(In Vivo)

PTER-IN-1 (100 mg/kg；腹腔注射；每日/单次) 在肥胖小鼠中可呈剂量依赖性地升高血浆 N-乙酰牛磺酸水平、减少食物摄入与体重、降低脂肪量、提升 Semaglutide (HY-114118) 的减重疗效，并预防 GLP-1R 激动剂停后的体重反弹[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male; diet-induced obese)[1]
Dosage: 100 mg/kg (acute studies; 1 week; 3 weeks; 27 days; 10 days rebound study)
Administration: i.p.; daily (chronic/rebound/combination studies); single dose (acute studies)
Result: Induced a dose-dependent increase in plasma N-acetyltaurine levels in lean mice, and increased levels up to 1 hour post-injection in lean mice and 2 hours post-injection in obese mice.
Reduced food intake at 6 and 18 hours post-single injection in obese mice.
Decreased cumulative food intake and reduced body weight over 8 days and 3 weeks of daily treatment in obese mice.
Resulted in loss of adipose mass with no changes in liver, kidney, or heart mass after 27 days of daily treatment.
When combined with semaglutide, further reduced cumulative food intake and lowered body weight compared to vehicle-treated obese mice over 1 week.
Prevented weight regain in obese mice switched from semaglutide to PTER-IN-1 after 15 days of semaglutide treatment; these mice maintained weight loss at a level comparable to mice continuing semaglutide therapy, whereas mice switched to vehicle gained weight.
分子量

372.37

Formula

C19H20N2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PTER-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTER-IN-13114432-21-9HDACHistone deacetylasesPTER-selective inhibitorobesityC57BL/6J mice
Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PTER-IN-1
目录号：
HY-185341
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z