2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. (R)-Niguldipine

(R)-Niguldipine， Niguldipine (HY-101390B) 的 R- 差向异构体，是一种钙通道 (calcium channel) 拮抗剂。(R)-Niguldipine 通过阻断钙通道，减少钙离子的跨膜内流，发挥血管舒张作用。(R)-Niguldipine 可抑制 U-46619 (HY-108566) 诱发的豚鼠 Langendorff 心脏冠状动脉收缩 (pID50 为 9.93)，对豚鼠骨骼肌膜上的钙通道结合位点有高亲和性 (Ki 为 8.10)，降低自发性高血压大鼠的血压 (pED30 为 5.55)。(R)-Niguldipine 可改善高血压、心绞痛、心律失常等心血管疾病。

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(R)-Niguldipine

(R)-Niguldipine Chemical Structure

CAS No. : 120054-86-6

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(R)-Niguldipine 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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  • 参考文献

生物活性

(R)-Niguldipine, a R-epimer of Niguldipine (HY-101390B), is a calcium channel antagonist. (R)-Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55). (R)-Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias[1].

分子量

609.71

Formula

C36H39N3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-Niguldipine 相关分类

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Keywords:

(R)-Niguldipine120054-86-6Calcium ChannelCa2+ channelsCa channelscoronary artery contractionguinea pigskeletal muscle membranesblood pressurespontaneously hypertensive ratshypertensionangina pectorisarrhythmiasInhibitorinhibitorinhibit

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目录号：
HY-101390D
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