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  3. (Rac)-Atomoxetine hydrochloride

(Rac)-Atomoxetine hydrochloride  (Synonyms: (Rac)-Tomoxetine hydrochloride; (Rac)-LY 139603)

目录号: HY-107370A
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(Rac)-Atomoxetine hydrochloride ((Rac)-Tomoxetine (hydrochloride); (Rac)-LY 139603) 是 Atomoxetine hydrochloride (HY-17385) 的外消旋体。Atomoxetine hydrochloride 是一种选择性去甲肾上腺素再摄取抑制剂 (noradrenaline reuptake),去甲肾上腺素 (NE)、5-羟色胺 (5-HT) 和多巴胺 (DA) 转运体的 Ki 值分别为 5、77 和 1451 nM。Atomoxetine hydrochloride 可以增加 PFC 中 DAEX 和 NEEX,从而增强儿茶酚胺能神经传递。Atomoxetine hydrochloride 是一种有效的Na+ 通道阻断剂 (VGSCs)。Atomoxetine hydrochloride 可用于注意力缺陷多动障碍 (ADHD) 的研究。

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(Rac)-Atomoxetine hydrochloride

(Rac)-Atomoxetine hydrochloride Chemical Structure

CAS No. : 82857-40-7

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生物活性

(Rac)-Atomoxetine hydrochloride ((Rac)-Tomoxetine (hydrochloride); (Rac)-LY 139603) is the racemic mixture of Atomoxetine hydrochloride (HY-17385). Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

分子量

291.82

Formula

C17H22ClNO

CAS 号
中文名称

外消旋盐酸托莫西汀杂质1;托莫西汀杂质1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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