OTUD3 蛋白, Human

OTUD3 Protein, Human is the recombinant human-derived OTUD3, expressed by E. coli , with tag Free labeled tag. ,

OTUD3 是一种去泛素化酶，能够水解 Lys-6 和 Lys-11 连接的多聚泛素链，同时也能水解异型（混合和分支）和同型链。它是能量代谢的重要调节因子，葡萄糖和脂肪酸通过 CBP 依赖性乙酰化触发其核转位。在细胞核中，OTUD3 通过去泛素化并稳定核受体 PPARD，调控与葡萄糖、脂质代谢以及氧化磷酸化相关的多种基因表达。此外，OTUD3 还作为核糖体质量控制（RQC）的负调节因子，通过介导 40S 核糖体蛋白 RPS10/eS10 和 RPS20/uS10 的去泛素化，拮抗 ZNF598 介导的 40S 泛素化。

Human

E. coli

Tag Free

Q5T2D3 (E52-D209)

23252

Partial

≥ 95%, as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 200mM NaCl, 20% glycerol, 1mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.