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  6. Regiafuran C

Regiafuran C 是一种兼具 TGF-βRI 抑制和抗纤维化活性的化合物。Regiafuran C 能够通过结合 TGF-βRI 并干扰 TGF-β/Smad 及 Wnt/β-catenin 信号通路，从而有效抑制肾纤维化。Regiafuran C 还具备自由基清除能力，但在 PGE2 竞争酶免疫分析中未显示出抗炎活性。Regiafuran C 可特异性阻断 Smad3-TGF-βRII 相互作用及抑制纤维化进程的能力，可用于研究肾纤维化。

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Regiafuran C

Regiafuran C Chemical Structure

CAS No. : 2059921-60-5

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Regiafuran C 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Regiafuran C is a compound with both TGF-βRI inhibitory and anti-fibrotic activities. Regiafuran C effectively inhibits renal fibrosis by binding to TGF-βRI and interfering with the TGF-β/Smad and Wnt/β-catenin signaling pathways. Regiafuran C also exhibits free radical scavenging activity, but shows no anti-inflammatory activity in PGE2 competitive enzyme immunoassays. The ability of Regiafuran C to specifically block the Smad3-TGF-βRII interaction and inhibit fibrotic processes allows its use in renal fibrosis research[1][2].

体外研究
(In Vitro)

Regiafuran C (10-40 μM; 24 h) 对人肾近端小管 HK-2 细胞无细胞毒性，但呈剂量依赖性降低 TGF-β1 刺激的人肾近端小管 HK-2 细胞中纤连蛋白、I 型胶原蛋白、N-钙黏蛋白和波形蛋白的表达[1]。
Regiafuran C (10-40 μM; 24 h) 以剂量依赖的方式抑制 TGF-β1 刺激的人肾近端小管 HK-2 细胞中 TGF-β/Smad 信号通路的激活，降低 Wnt1、Wnt3a、GSK-3β、β-catenin、MMP7、MMP9，TGF-βRII、TGF-β1、p-Smad3、p-Smad2 和 Smad4 的水平，[1]。
Regiafuran C (40 μM; 24 h) 可显著降低 TGF-β1 诱导的人肾近端小管 HK-2 细胞中纤连蛋白、Ⅰ型胶原、N-钙黏蛋白和波形蛋白的 mRNA 表达水平[1]。
Regiafuran C (40 μM; 24 h) 可降低经 TGF-β1 刺激的人肾近端小管 HK-2 细胞中纤连蛋白、I 型胶原蛋白、N-钙黏蛋白和波形蛋白的蛋白水平，该结果由免疫荧光染色检测得出[1]。
Regiafuran C (40 μM; 24 h) 可在 TGF-β1 刺激的人肾近端小管 HK-2 细胞中阻断 Smad3 与 TGF-βRII 之间的相互作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Regiafuran C 相关抗体:

Western Blot Analysis[1]

Cell Line: human renal proximal tubular HK-2 cells, TGF-β1-stimulated human renal proximal tubular HK-2 cells
Concentration: 10-40 μM
Incubation Time: 24 h (co-incubated with TGF-β1)
Result: Maintained cell viability at ≥90% of control levels across all tested concentrations.
Dose-dependently downregulated TGF-β1-induced upregulation of fibronectin, collagen I, N-cadherin, and vimentin.\nDose-dependently downregulated TGF-β1-induced upregulation of TGF-βRII, TGF-β1, p-Smad3, p-Smad2, and Smad4.\nDose-dependently downregulated TGF-β1-induced upregulation of Wnt1, Wnt3a, GSK-3β, β-catenin, MMP7, and MMP9.

Real Time qPCR[1]

Cell Line: TGF-β1-stimulated human renal proximal tubular HK-2 cells
Concentration: 40 μM
Incubation Time: 24 h (co-incubated with TGF-β1)
Result: Significantly reduced TGF-β1-induced upregulation of fibronectin, collagen I, N-cadherin, and vimentin mRNA levels.

Immunofluorescence[1]

Cell Line: TGF-β1-stimulated human renal proximal tubular HK-2 cells
Concentration: 40 μM
Incubation Time: 24 h (co-incubated with TGF-β1)
Result: Reduced the increased fluorescence intensity of fibronectin, collagen I, N-cadherin, and vimentin induced by TGF-β1 stimulation.\nReduced the increased fluorescence intensity of TGF-β1 and β-catenin induced by TGF-β1 stimulation.
分子量

408.49

Formula

C25H28O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Regiafuran C 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Regiafuran C2059921-60-5TGF-β/Smad pathwayWnt/β-catenin pathwaycollagen ISmad3TGF-βRIIN-cadherinTGF-βRIfibronectinHK-2 cellsrenal fibrosisInhibitorinhibitorinhibit

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