2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. RXR antagonist 6

RXR antagonist 6 (Compound 34) 是一种选择性的部分类视黄醇 X 受体 (RXR) 拮抗剂。RXR antagonist 6 对人 RXRα/β/γ 亚型均无激动活性，但能强效抑制 RXR 完全激动剂 (如 Bezafibrate (HY-B0637)) 诱导的受体激活，其 IC50 值为 2.7 μM。RXR antagonist 6 可增强 PMA (HY-18739) 诱导的 THP-1 细胞分化。RXR antagonist 6 可用于癌症、代谢性疾病和神经系统疾病的研究，如淋巴瘤。

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RXR antagonist 6

RXR antagonist 6 Chemical Structure

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RXR antagonist 6 相关抗体

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RXRα RXRβ RXRγ

  • 生物活性

  • 纯度 & 产品资料

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生物活性

RXR antagonist 6 (Compound 34) is a selective partial retinoid X receptor (RXR) antagonist. RXR antagonist 6 shows no agonistic activity for any of the human RXRα/β/γ subtypes but it can strongly inhibit the receptor activation induced by full agonists of RXR (such as Bezafibrate (HY-B0637)) with an IC50 of 2.7 μM. RXR antagonist 6 can enhance PMA (HY-18739)-induced THP-1 cell differentiation. RXR antagonist 6 can be used for the research of cancer, metabolic and neurological disease, such as lymphoma[1].

分子量

404.46

Formula

C23H24N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RXR antagonist 6 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RXR antagonist 6RXR antagonist6RXR antagonist-6RAR/RXRRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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RXR antagonist 6
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