2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. Reactive Oxygen Species (ROS) Apoptosis p38 MAPK PERK
  4. (S)-IP-DK143

(S)-IP-DK143 是一种聚合物胶束制剂。(S)-IP-DK143 抑制宫颈癌细胞增殖，诱导 ROS 介导的细胞凋亡 (Apoptosis)，引发线粒体功能障碍。(S)-IP-DK143 激活宫颈癌细胞中的 p38 MAPK 信号通路，升高 p38 磷酸化水平，同时轻微降低 ERK 的磷酸化水平。(S)-IP-DK143 可用于宫颈癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(S)-IP-DK143

(S)-IP-DK143 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

(S)-IP-DK143 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(S)-IP-DK143 is a polymeric micellar formulation. (S)-IP-DK143 inhibits the proliferation of cervical cancer cells, induces ROS-mediated apoptosis, and triggers mitochondrial dysfunction. (S)-IP-DK143 activates the p38 MAPK signaling pathway in cervical cancer cells, increases the phosphorylation level of p38, and slightly reduces the phosphorylation level of ERK. (S)-IP-DK143 can be used for the research of cervical cancer[1].

体外研究
(In Vitro)

(S)-IP-DK143 (DK143) (1-100 μM; 24 h) 可强效抑制 HeLa 细胞增殖，处理 24 h 后的 IC50 为 20.60 μM，并可诱导凋亡形态学改变[1]。
(S)-IP-DK143 (30 μM; 24 h) 可在 HeLa 细胞中诱导显著的线粒体分裂，使线粒体长度降至未处理组的 17.39%[1]。
(S)-IP-DK143 (1-30 μM; 24 h) 可激活 HeLa 细胞中的 p38 MAPK 信号通路，使 p38 磷酸化水平升高至未处理组的 398.9%，同时轻微降低 ERK 的磷酸化水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-IP-DK143 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HeLa cervical cancer cells
Concentration: 0, 1, 3, 10, 30, and 100 μM
Incubation Time: 24 h
Result: Induced concentration-dependent reduction in cell viability, with an IC50 value of 20.60 μM.
Displayed apoptotic morphological features including cell shrinkage, rounding, and detachment from the culture surface.

Western Blot Analysis[1]

Cell Line: HeLa cervical cancer cells
Concentration: 0, 1, 3,
and 30 μM
Incubation Time: 24 h
Result: Significantly increased p38 phosphorylation to 398.9 ± 24.8% relative to the untreated control (with total p38 levels unchanged) at 30 μM.
Slightly reduced ERK phosphorylation.
分子量

502.60

Formula

C31H34O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(S)-IP-DK143 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-IP-DK143Reactive Oxygen Species (ROS)Apoptosisp38 MAPKPERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasepolymeric micellar formulationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
(S)-IP-DK143
目录号：
HY-181817
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z