2. Metabolic Enzyme/Protease
  3. β-glucuronidase Cytochrome P450
  4. Saccharolactone

Saccharolactone 是一种强效的口服活性 β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂。糖内酯可显著降低大鼠胆汁中胆汁内源性 β-葡萄糖醛酸酶的活性。Saccharolactone 可在体外稳定葡萄糖醛酸苷代谢物。Saccharolactone 也是 CYP1A2、2D6、3A4 和 2C8 同工酶的强效抑制剂 (IC50 < 4 mM)。

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Saccharolactone

Saccharolactone Chemical Structure

CAS No. : 389-36-6

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Saccharolactone 的其他形式现货产品:

Customer Review

Other Forms of Saccharolactone:

Saccharolactone 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM)[1][2][3].

IC50 & Target[1][2][3]

CYP1A2

<4 mM (IC50)

CYP2D6

<4 mM (IC50)

CYP3A4

<4 mM (IC50)

CYP2C8

<4 mM (IC50)

分子量

192.12

Formula

C6H8O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Saccharolactone 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Saccharolactone389-36-6β-glucuronidaseCytochrome P450GUSBCYPsrat bilestabilize glucuronide metabolitesInhibitorinhibitorinhibit

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