2. Apoptosis
  3. MDM-2/p53
  4. Safrole oxide

Safrole oxide 是一种 p53 调节剂， 可上调 p53 抑癌蛋白的表达，将细胞周期阻滞与凋亡过程相关联。Safrole oxide 可诱导肺癌细胞发生凋亡，且不会引发坏死。Safrole oxide 可用于肺癌相关研究。

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Safrole oxide

Safrole oxide Chemical Structure

CAS No. : 7470-44-2

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Safrole oxide 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Safrole oxide is a p53 modulator that upregulates the expression of the p53 tumor suppressor protein, linking cell cycle arrest to the apoptotic process. Safrole oxide induces apoptosis in lung cancer cells without triggering necrosis. Safrole oxide can be used in lung cancer-related research[1].

体外研究
(In Vitro)

Safrole oxide (112.36-449.44 μM; 24-48 h) 可呈剂量和时间依赖性降低人肺癌 A549 细胞的存活率，与对照组细胞相比，其存活率在 (24 h, 449.44 μM) 时降至 57.78%，在 (48 h, 449.44 μM) 时降至 12.62%[1]。
Safrole oxide (112.36-449.44 μM; 24 h) 可诱导人肺癌 A549 细胞发生染色质固缩和核碎裂--这是细胞凋亡的标志性特征[1]。
Safrole oxide (449.44 μM; 48 h) 处理人肺癌 A549 细胞 48 小时后不会诱导细胞坏死，这一点可通过其与对照组细胞相比无变化的 LDH 释放水平得到证实[1]。
Safrole oxide (224.72 μM; 24-48 h) 可在处理 24 至 48 小时后，将人肺癌 A549 细胞完全阻滞于 G1 期、部分阻滞于 G2-M 期，从而抑制细胞周期进程并诱导细胞凋亡[1]。
Safrole oxide (224.72 μM; 24 h) 可显著上调人肺癌 A549 细胞中 P53 蛋白的表达，但对 H-Ras 蛋白的表达无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Safrole oxide 相关抗体:

Cell Viability Assay[1]

Cell Line: A549 human lung cancer cells
Concentration: 112.36 μM; 224.72 μM; 449.44 μM
Incubation Time: 24 h; 48 h
Result: Reduced cell viability to 85.39% (112.36 μM, 24 h), 78.85% (224.72 μM, 24 h) and 57.78% (449.44 μM, 24 h) relative to control.
Reduced cell viability to 68.73% (112.36 μM, 48 h, P < .01), 29.85% (224.72 μM, 48 h)

Apoptosis Analysis[1]

Cell Line: A549 human lung cancer cells
Concentration: 112.36 μM; 224.72 μM; 449.44 μM
Incubation Time: 24 h
Result: Initiated chromatin condensation and nuclear fragmentation in A549 cells.

Cell Cycle Analysis[1]

Cell Line: A549 human lung cancer cells
Concentration: 224.72 μM
Incubation Time: 24 h; 48 h
Result: Decreased S phase percentage to 16.78% and increased G2-M phase percentage to 14.28% after 24 h treatment, compared to control (S phase 20.03%, G2-M phase 7.30%).
Decreased S phase percentage to 0%, increased G0-G1 phase percentage to 74.73%, and increased G2-M phase percentage to 25.27% after 48 h treatment, compared to control (S phase 30.59%, G0-G1 phase 64.51%, G2-M phase 4.98%).

Immunofluorescence[1]

Cell Line: A549 human lung cancer cells
Concentration: 224.72 μM
Incubation Time: 24 h
Result: Increased relative fluorescence intensity of P53 protein from 31.14 to 51.73, indicating dramatic up-regulation.
Changed relative fluorescence intensity of H-Ras protein from 24.05 to 31.52, showing no significant difference.
分子量

178.18

Formula

C10H10O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Safrole oxide 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Safrole oxide7470-44-2MDM-2/p53nuclear fragmentationlung cancer cellsH-Raschromatin condensationp53A549 human lung cancer cellscell cycle arrestapoptosisG2-M phaseG1 phaseInhibitorinhibitorinhibit

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