2. Anti-infection Others Cell Cycle/DNA Damage
  3. Bacterial Insecticide DNA/RNA Synthesis
  4. Satranidazole

Satranidazole 是一种具有高电子亲和力的、口服有效的杀虫剂和抗菌剂。Satranidazole 会形成还原型硝基中间体，该中间体会与 DNA 相互作用，导致螺旋不稳定、链断裂和胸腺嘧啶衍生物释放。Satranidazole 对阴道毛滴虫和胎儿毛滴虫具有抗滴虫活性，在肝阿米巴病和盲肠阿米巴病的啮齿动物模型中具有抗阿米巴活性。Satranidazole 可抑制噬菌体 φX174 DNA 的复制。Satranidazole 可用于盲肠阿米巴病、滴虫病和厌氧菌感染的相关研究。

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Satranidazole

Satranidazole Chemical Structure

CAS No. : 56302-13-7

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Other Forms of Satranidazole:

Satranidazole 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Satranidazole is an orally effective insecticide and antimicrobial agent with high electron affinity. Satranidazole forms reduced nitro intermediates, which interact with DNA, causing helix instability, strand breakage and release of thymidine derivatives. Satranidazole exhibits antitrichomonal activity against Trichomonas vaginalis and Trichomonas foetus, and antiamoebic activity in rodent models of hepatic amoebiasis and caecal amoebiasis. Satranidazole inhibits the replication of bacteriophage φX174 DNA. Satranidazole can be used in research related to caecal amoebiasis, trichomoniasis and anaerobic bacterial infections[1][2].

体外研究
(In Vitro)

Satranidazole 在化合物-核苷酸比例为 0.5:1 和 1:1 时会引发大肠杆菌 DNA 发生广泛损伤，包括螺旋失稳、链断裂、胸苷释放及黏度降低[1]。
Satranidazole 在化合物-核苷酸比例为 1:1 时可灭活噬菌体 φX174 DNA，其 T37 为 2.41 h、R37 为 3.85，提示存在具有生物学相关性的 DNA 损伤[1]。
Satranidazole (8 小时) 在体外可强效抑制厌氧菌的参考菌株和临床分离株，针对 50 株临床分离株的 MIC90 为 0.25 mg/L，且在大多数受试菌株中，其 MIC 值低于对照药物[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Satranidazole 相关抗体:
体内研究
(In Vivo)

Satranidazole 在盲肠阿米巴病小鼠模型中表现出优于 Metronidazole (HY-B0318) 的活性[1]。
Satranidazole 在金黄仓鼠的肝、盲肠或合并溶组织内阿米巴感染模型中表现出杀阿米巴活性[1]。
Satranidazole 在皮下感染阴道毛滴虫或胎儿毛滴虫的小鼠模型中表现出优于 Metronidazole 的活性[1]。
Satranidazole (2-32 mg/kg; p.o.; 共 3 次) 对小鼠致死性坏死梭杆菌败血症表现出强效的保护活性，其 ED50 为 2.10 mg/kg[2]。
Satranidazole (10-100 mg/kg；口服；给药 2 次) 对小鼠皮下脆弱拟杆菌脓肿表现出剂量依赖性杀菌活性，在 10 mg/kg 剂量下可使菌落形成单位 (cfu) 降低 3 个对数级，在 100 mg/kg 剂量下可实现完全灭菌[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MF2 strain (male, 18-20 g)[2]
Dosage: 2, 4, 8, 16, 32 mg/kg
Administration: p.o.; at 24, 48, 72, and 96 hours post-infection
Result: Exhibited an ED50 of 2.10 mg/kg, which was at least three-fold lower than the ED50 values of comparator drugs.
Animal Model: MF2 strain (male, 18-20 g)[2]
Dosage: 10 mg/kg; 30 mg/kg; 100 mg/kg
Administration: p.o.; twice at 0 and 24 hours post-infection
Result: Produced a 3-log reduction in Bacteroides fragilis colony-forming units (cfu) in abscesses at 10 mg/kg.
Achieved complete sterilization of abscesses at 100 mg/kg.
分子量

289.27

Formula

C8H11N5O5S
CAS 号
中文名称

沙硝唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Satranidazole 相关分类

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Keywords:

Satranidazole56302-13-7沙硝唑BacterialInsecticideDNA/RNA SynthesisEntamoeba histolyticaTrichomonas foetusPropionobacterium acnesGram-negative anaerobic bacteriabacteriophage φX174 DNArodent modelsTrichomonas vaginalisFusobacterium necrophorumGram-positive anaerobic bacteriaBacteroides fragilisInhibitorinhibitorinhibit

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