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  4. SDZ 51641

SDZ 51641 是一种具有口服活性的脂肪酸氧化抑制剂。SDZ 51641 可通过降低脂肪酸氧化，进而剥夺糖异生过程所需的能量及辅因子，从而降低糖尿病模型的血糖水平。SDZ 51641 可用于糖尿病的研究。

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SDZ 51641

SDZ 51641 Chemical Structure

CAS No. : 91456-99-4

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SDZ 51641 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SDZ 51641 is an orally active fatty acid oxidation inhibitor. By reducing fatty acid oxidation, SDZ 51641 deprives the gluconeogenesis process of required energy and cofactors, thereby lowering blood glucose levels in diabetic models. SDZ 51641 can be used in diabetes research[1].

体内研究
(In Vivo)

SDZ 51641（70-100 μmol/kg；口服；1-11 天）在 18 小时禁食正常 Sprague‑Dawley 大鼠与 Streptozotocin (STZ) (HY-13753) 诱导糖尿病大鼠中降低脂肪酸氧化与血糖水平且无外周毒性[1]。
SDZ 51641 (700 µmol/kg；口服；每日一次；持续 28 天) 可使正常 Sprague Dawley 大鼠的体重和睾丸重量较对照组降低，同时使肝脏重量升高[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague‑Dawley rats treated STZ[1]
Dosage: 70 µmol/kg
Administration: p.o.; daily; 11 days
Result: Inhibited hepatic fatty acid oxidation, decreased β‑hydroxybutyrate levels, reduced blood glucose production, and lowered serum glucose levels, while avoiding toxic effects on peripheral tissues such as the testes.
分子量

220.31

Formula

C14H20O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SDZ 51641 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDZ 5164191456-99-4SDZ51641SDZ-51641Drug IntermediateDrug Iintermediatelong-chain acyl dehydrogenasefatty acid oxidationSTZ-induced diabetic ratsgluconeogenesisSprague Dawley ratstesticular toxicitycarnitine palmitoyl transferase 2intramitochondrial CoAacetyl-CoAnon-insulin-dependent diabetes mellitusInhibitorinhibitorinhibit

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目录号：
HY-182438
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