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GluR1

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By Targets:	iGluR (9) Reference Standards (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Neurological Disease (9)
Oligonucleotides:	小干扰RNA (1) 小干扰RNA套装（人源） (1)

抑制剂 & 激动剂

抗体

寡核苷酸

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Targets Recommended: mGluR iGluR

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-101528

IDRA 21	iGluR	Neurological Disease
IDRA 21 是 AMPA 受体的阳性和口服活性调节剂。IDRA 21 通过 GluR1/2 受体促进兴奋性神经传递。IDRA 21 具有研究认知/记忆障碍的潜力，包括那些与衰老相关的疾病。

HY-12509

PEPA	iGluR	Neurological Disease
PEPA 是一种 AMPA 受体变构增效剂。PEPA 对 AMPA 受体的翻转形式表现出优先作用。与含有 GluR1 的受体相比，PEPA 是一种更有效的抑制含有 GluR3 和 GluR4 的受体脱敏的抑制剂。PEPA 具有抗焦虑作用。

HY-104020A

Philanthotoxin 74 dihydrochloride PhTx 74 dihydrochloride	iGluR	Neurological Disease
Philanthotoxin 74 dihydrochloride (PhTx 74) 是 AMPAR 的拮抗剂, 抑制 GluR3 和 *GluR1* 的 IC₅₀ 值分别为 263 和 296 nM。

HY-13456

LY-404187	iGluR	Neurological Disease
LY-404187 是有效的，选择性和中枢活性的 AMPA 受体的正变构调节剂，作用于 GluR1i，GluR2i，GluR2o，GluR3i 和 GluR4i 的 EC₅₀ 值分别为 5.65、0.15、1.44、1.66 和 0.21 µM。LY-404187 有潜力用于许多精神疾病和神经退行性疾病的研究。

HY-103229

Cl-HIBO	iGluR	Neurological Disease
Cl-HIBO 是一种高度亚型选择性 GluR1/2 激动剂 (EC₅₀ 分别为 4.7 和 1.7 μM)。Cl-HIBO 是一种有效的 AMPA 受体激动剂 (IC₅₀=0.22 μM)。Cl-HIBO 具有脱敏特性。

HY-19433A

(S)-ATPO	iGluR	Neurological Disease
(S)-ATPO 是 ATPO 的 (S) 型对映体，ATPO 是 GluR1-4 (AMPA-preferring) 受体的竞争性拮抗剂。

HY-RS05791

GRIA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GRIA1 Human Pre-designed siRNA Set A 包括针对 GRIA1 (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。

GRIA1 Human Pre-designed siRNA Set A GRIA1 Human Pre-designed siRNA Set A

HY-104020B

Philanthotoxin 74 diTFA PhTx 74 diTFA	iGluR	Neurological Disease
Philanthotoxin 74 (PhTx 74) diTFA 是 AMPAR 的拮抗剂, 抑制 GluR3 和 *GluR1* 的 IC₅₀ 值分别为 263 nM 和 296 nM。

HY-101528R

IDRA 21 (Standard)	iGluR Reference Standards	Neurological Disease
IDRA 21 (Standard) 是 IDRA 21 (HY-101528) 的分析标准品。本产品用于研究及分析应用。IDRA 21 是 AMPA 受体的阳性和口服活性调节剂。IDRA 21 通过 GluR1/2 受体促进兴奋性神经传递。IDRA 21 具有研究认知/记忆障碍的潜力，包括那些与衰老相关的疾病。

HY-131691

NMDAR blocker 1	iGluR	Neurological Disease
NMDAR blocker 1 是一种 NMDA 受体通道阻滞剂，其 IC₅₀ 为 5.0 μM。NMDAR blocker 1 具有快速的开关阻滞动力学特征和强电压依赖性，且不与谷氨酸或甘氨酸竞争结合位点。NMDAR blocker 1 可阻止谷氨酸/NMDA 诱导的细胞内 Ca²⁺超载，调控谷氨酸-一氧化氮-cGMP (glutamate-nitric oxide-cGMP) 通路。NMDAR blocker 1 可在体外抑制培养的小脑和海马神经元的兴奋性毒性神经退行性变。NMDAR blocker 1 可减轻高氨血症诱导的兴奋性毒性小鼠模型中的兴奋性毒性损伤。NMDAR blocker 1 可用于神经退行性疾病的研究。

Cat. No.	Compare	Product Name	Application	Reactivity	图片

HY-P86115

	Glutamate Receptor 1 (AMPA Subtype) Antibody (YA5807) GRIA1; GLUH1; GluR1; Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic; AMPA 1; GluA1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Glutamate Receptor 1 (AMPA Subtype) Antibody (YA5807) 是一个兔来源、无偶联标记、抗 Glutamate Receptor 1 (AMPA Subtype) 的 IgG 单克隆抗体。

HY-P82336

	Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081) GRIA1; GLUH1; GluR1; Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic; AMPA 1; GluA1	WB	Human, Rat
	Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081) 是一个兔来源、无偶联标记、抗磷酸化 Glutamate Receptor 1 (AMPA Subtype) (Ser845) 的 IgG 单克隆抗体。

HY-P80407

	Glutamate Receptor 1 (AMPA Subtype) Antibody (YA407)	WB, IHC-P, IP	Mouse, Rat
	Glutamate Receptor 1 (AMPA Subtype) Antibody (YA407) 是一个兔来源、无偶联标记、抗 Glutamate Receptor 1 (AMPA Subtype) 的 IgG 单克隆抗体。

HY-P82336A

	Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)(PBS only) GRIA1; GLUH1; GluR1; Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic; AMPA 1; GluA1	WB	Human, Rat
	Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081) 是一个兔来源、无偶联标记、抗磷酸化 Glutamate Receptor 1 (AMPA Subtype) (Ser845) 的 IgG 单克隆抗体。

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GRIA1 Human Pre-designed siRNA Set A		小干扰RNA 小干扰RNA套装（人源）
GRIA1 Human Pre-designed siRNA Set A 包括针对 GRIA1 (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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