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By Targets:	Adenosine Receptor (1) Apoptosis (1) Autophagy (1) Bacterial (1) EGFR (1) GABA Receptor (3) Isotope-Labeled Compounds (1) Opioid Receptor (1) Reference Standards (1) TRP Channel (1)
By Research Areas:	Cancer (1) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (6)

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-B1833

Afloqualone HQ-495	GABA Receptor	Neurological Disease
氟喹酮 Afloqualone (HQ-495) 是一种具有口服活性的中枢性肌肉松弛剂和抗眩晕剂，可增加外侧前庭核神经元 GABA 受体的敏感性。Afloqualone (HQ-495) 能够用于腰痛和颈臂肩综合征的研究。

HY-171846

LY3526318	TRP Channel	Neurological Disease Inflammation/Immunology
LY3526318 是一种口服有效、选择性 TRPA1 拮抗剂 (IC₅₀=5-6μM)。LY3526318 阻断 TRPA1 通道，抑制由该通道介导的疼痛信号转导，发挥镇痛活性。LY3526318 主要用于慢性疼痛相关领域的研究，如糖尿病周围神经性疼痛、慢性下腰痛以及骨关节炎引发的疼痛等的研究。

HY-17391

Pamabrom	Adenosine Receptor	Endocrinology
巴马溴 Pamabrom 是一种口服有效、靶向阿片受体 (opioid receptor)-NO-cGMP-K⁺ 通道通路的利尿剂。Pamabrom 通过激活该通路发挥外周镇痛活性，具体机制为激活阿片受体，促使一氧化氮释放，进而影响环磷酸鸟苷和 K⁺ 通道，产生镇痛效果。Pamabrom 可用于经前期综合征和原发性痛经等领域的研究。

HY-P990071

Fepixnebart LY-3016859	EGFR	Neurological Disease Metabolic Disease Inflammation/Immunology
Fepixnebart (LY3016859) 是一种人源化单克隆 hIgG4 抗体，其高亲和力结合并中和 TGFα 和表皮调节蛋白。Fepixnebart 可用于糖尿病肾病和广谱慢性疼痛，包括糖尿病周围神经性疼痛 (DPNP)、骨关节炎 (OA) 的体征和症状以及慢性腰痛 (CLBP) 的研究。

HY-13777B

Zoledronic acid disodium tetrahydrate Zoledronate disodium tetrahydrate; CGP 42446 disodium tetrahydrate; CGP42446A disodium tetrahydrate; ZOL 446 disodium tetrahydrate	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic Acid (Zoledronate) disodium tetrahydrate 是第三代含氮二磷酸盐，具有高效的抗骨质再吸收活性。Zoledronic Acid disodium tetrahydrate 能抑制破骨细胞的分化和凋亡。Zoledronic Acid disodium tetrahydrate 也有抗癌作用。

HY-B1833R

Afloqualone (Standard) HQ-495 (Standard)	Reference Standards GABA Receptor	Neurological Disease
氟喹酮 (标准品) Afloqualone (Standard) 是 Afloqualone 的分析标准品。本产品用于研究及分析应用。Afloqualone (HQ-495) 是一种具有口服活性的中枢性肌肉松弛剂和抗眩晕剂，可增加外侧前庭核神经元 GABA 受体的敏感性。Afloqualone (HQ-495) 能够用于腰痛和颈臂肩综合征的研究。

HY-109064

Loxicodegol Oxycodegol; NKTR-181	Opioid Receptor	Neurological Disease
Loxicodegol (Oxycodegol) 是一种一流的、长效的、选择性的 mu阿片类(mu-opioid) 激动剂，与传统的 mu 阿片类激动剂相比，其结构特性降低了其穿过血脑屏障的速率。Loxicodegol 具有口服活性。

HY-B1833S

Afloqualone-d7 HQ-495-d₇	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Afloqualone-d₇ (HQ-495-d₇) 是氘代标记的 Afloqualone. Afloqualone (HQ-495) 是一种具有口服活性的中枢性肌肉松弛剂和抗眩晕剂，可增加外侧前庭核神经元 GABA 受体的敏感性。Afloqualone (HQ-495) 能够用于腰痛和颈臂肩综合征的研究。

Cat. No.	Product Name	Target	Research Area	图片

HY-P990071

Fepixnebart LY-3016859	EGFR	Neurological Disease Metabolic Disease Inflammation/Immunology
Fepixnebart (LY3016859) 是一种人源化单克隆 hIgG4 抗体，其高亲和力结合并中和 TGFα 和表皮调节蛋白。Fepixnebart 可用于糖尿病肾病和广谱慢性疼痛，包括糖尿病周围神经性疼痛 (DPNP)、骨关节炎 (OA) 的体征和症状以及慢性腰痛 (CLBP) 的研究。

Cat. No.	Product Name	Chemical Structure

HY-B1833S

Afloqualone-d7
Afloqualone-d₇ (HQ-495-d₇) 是氘代标记的 Afloqualone. Afloqualone (HQ-495) 是一种具有口服活性的中枢性肌肉松弛剂和抗眩晕剂，可增加外侧前庭核神经元 GABA 受体的敏感性。Afloqualone (HQ-495) 能够用于腰痛和颈臂肩综合征的研究。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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