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chromosomes 1

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By Targets:	Aurora Kinase (1) Biochemical Assay Reagents (1) CDK (2) Endogenous Metabolite (1) Fluorescent Dye (1) Nucleoside Antimetabolite/Analog (2)
By Research Areas:	Cancer (3) Neurological Disease (2)

抑制剂 & 激动剂

荧光染料

生化试剂

抗体

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-W127705

Quinacrine mustard dihydrochloride 1 篇文献验证	Fluorescent Dye	Others
Quinacrine mustard dihydrochloride 是一种荧光染料。Quinacrine mustard dihydrochloride 作为一种多环芳香剂，可作为诱变剂诱导细菌的突变体。Quinacrine mustard dihydrochloride 诱导细胞周期停滞在 G2/M 期。Quinacrine mustard dihydrochloride 具有研究植物、动物或人类染色体的潜力。

HY-157549A

Brivoligide sodium AYX1 sodium	Nucleoside Antimetabolite/Analog	Neurological Disease
Brivoligide (AYX1) sodium 是一种双链、不受保护的 23 碱基对寡核苷酸。Brivoligide sodium 可以减轻术后急性疼痛。Brivoligide sodium 模拟了染色体上 EGR1 通常结合的 DNA 序列。

HY-W541025

Deoxyribonucleic acid	Biochemical Assay Reagents	Others
Deoxyribonucleic acid 是由两条多核苷酸链相互缠绕形成双螺旋结构的聚合物。Deoxyribonucleic acid 存在于所有正在分裂的细胞中，是染色体的基本成分。

HY-157549

Brivoligide AYX1	Nucleoside Antimetabolite/Analog	Neurological Disease
Brivoligide (AYX1) 是一种双链、不受保护的 23 碱基对寡核苷酸。Brivoligide 可以减轻术后急性疼痛。Brivoligide 模拟了染色体上 EGR1 通常结合的 DNA 序列。

HY-E70653

CDK1/CycB1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 是一种细胞周期依赖性激酶，作为丝氨酸/苏氨酸蛋白激酶发挥作用，在细胞周期调控中起关键作用。CDK1/CycB1 Recombinant Human Active Protein Kinase 是 CDK1 的直系同源物。CDK1/cyclin B1 复合物通过磷酸化多种蛋白质来启动有丝分裂进入，从而使染色体凝聚、破坏核膜，并使微管聚合得以附着并分离染色体。

HY-123279

OM137	Aurora Kinase CDK	Cancer
OM137 是一种 aurora 激酶抑制剂，IC₅₀ 为 21.7 μM (Aurora A 激酶) 和 2.4 μM (Aurora B 激酶)。OM137 还抑制 Cdk1/cyclinB 和 Cdk5/p25，IC₅₀ 约为 20 μM。OM137 可降低染色体动粒处的纺锤体检查点信号蛋白 (Mad2 和 BubR1) 含量。

HY-13224A

AZD4877 hydrochloride	Endogenous Metabolite	Cancer
AZD4877 hydrochloride是一种合成的动力蛋白抑制剂，具有潜在的抗肿瘤活性。AZD4877选择性地抑制微管动力蛋白KSP（也称为kinesin-5或Eg5），可能导致有丝分裂纺锤体组装的抑制。AZD4877的作用可能激活纺锤体组装检查点，导致有丝分裂阶段的细胞周期停滞。AZD4877可诱导活跃分裂的肿瘤细胞死亡。AZD4877由于不涉及后有丝分裂过程，可能更不容易引起与微管靶向化合物相关的外周神经病。AZD4877对双极纺锤体的形成和姐妹染色体的正确分离至关重要。

Cat. No.	Product Name	Type

HY-W127705

Quinacrine mustard dihydrochloride 1 篇文献验证	Fluorescent Dye
Quinacrine mustard dihydrochloride 是一种荧光染料。Quinacrine mustard dihydrochloride 作为一种多环芳香剂，可作为诱变剂诱导细菌的突变体。Quinacrine mustard dihydrochloride 诱导细胞周期停滞在 G2/M 期。Quinacrine mustard dihydrochloride 具有研究植物、动物或人类染色体的潜力。

Cat. No.	Product Name	Type

HY-W541025

Deoxyribonucleic acid	Biochemical Assay Reagents
Deoxyribonucleic acid 是由两条多核苷酸链相互缠绕形成双螺旋结构的聚合物。Deoxyribonucleic acid 存在于所有正在分裂的细胞中，是染色体的基本成分。

Cat. No.	Compare	Product Name	Application	Reactivity	图片

HY-P80894

	SMC1A Antibody (YA673) Chromosome segregation protein SmcB; DXS423E; KIAA0178; MGC138332; Sb1.8; Segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1 (structural maintenance of chromosomes 1 yeast) like 1; SMC1; SMC1 structural maintenance of chromoso	WB, ICC/IF	Human
	SMC1A Antibody (YA673) 是一个小鼠来源、无偶联标记、抗 SMC1A 的 IgG1 单克隆抗体。

HY-P85502

	SMC1A(N-term) Antibody (YA5194) Chromosome segregation protein SmcB; DXS423E; KIAA0178; MGC138332; Sb1.8; Segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1; structural maintenance of chromosomes 1 yeast; like 1; SMC1; SMC1 structural maintenance of chromosomes 1 like 1; SMC1A; SMC1A_HUMAN; SMC1alpha; SMC1L1; SMCB; Structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A.	WB, IHC-P, FC	Human
	SMC1A(N-term) Antibody (YA5194) 是一个小鼠来源、无偶联标记、抗 SMC1A(N-term) 的单克隆抗体。

HY-P85503

	SMC1A(C-term) Antibody (YA5195) Chromosome segregation protein SmcB; DXS423E; KIAA0178; MGC138332; Sb1.8; Segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1; structural maintenance of chromosomes 1 yeast; like 1; SMC1; SMC1 structural maintenance of chromosomes 1 like 1; SMC1A; SMC1A_HUMAN; SMC1alpha; SMC1L1; SMCB; Structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A.	WB, ICC/IF	Human
	SMC1A(C-term) Antibody (YA5195) 是一个小鼠来源、无偶联标记、抗 SMC1A(C-term) 的单克隆抗体。

HY-P80894A

	SMC1A Antibody (YA673)(PBS only) Chromosome segregation protein SmcB; DXS423E; KIAA0178; MGC138332; Sb1.8; Segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1 (structural maintenance of chromosomes 1 yeast) like 1; SMC1; SMC1 structural maintenance of chromoso	WB, ICC/IF	Human
	SMC1A Antibody (YA673) 是一个小鼠来源、无偶联标记、抗 SMC1A 的 IgG1 单克隆抗体。

HY-P87031

	Phospho-SMC1 (S957) Antibody (YA6724) CDLS2 antibody; DKFZp686L19178 antibody; DXhXs423e antibody; DXS423E antibody; KIAA0178 antibody; MGC138332 antibody; OTTHUMP00000061876 antibody; RP6 29D12.1 antibody; SB1.8 antibody; Segregation of mitotic chromosomes 1 antibody; CDLS2 antibody; DKFZp686L19178 antibody; DXhXs423e antibody; DXS423E antibody; KIAA0178 antibody; MGC138332 antibody; OTTHUMP00000061876 antibody; RP6 29D12.1 antibody; SB1.8 antibody; Segregation of mitotic chromosomes 1 antibody; Segregation of mitotic chromosomes like 1 antibody; SMC 1 antibody; SMC protein 1B antibody; SMC-1-beta antibody; SMC-1B antibody; SMC1 antibody; SMC1A antibody; SMC1alpha antibody; SMC1alpha protein antibody; SMC1B antibody; SMC1B_HUMAN antibody; SMC1BETA antibody; SMC1beta protein antibody; SMC1L1 antibody; SMC1L2 antibody; SMCB antibody; Structural maintenance of chromosome 1 like 1 protein antibody; Structural maintenance of chromosome 1 like 2 protein antibody; Structural maintenance of chromosomes 1A antibody; Structural maintenance of chromosomes 1B antibody; Structural maintenance of chromosomes protein 1B antibody;	WB, IHC-P, ICC/IF	Human
	Phospho-SMC1 (S957) Antibody (YA6724) 是一个兔来源、无偶联标记、抗磷酸化 SMC1 (S957) 的 IgG 单克隆抗体。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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