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lactone ring

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By Targets:	Antibiotic (2) Bacterial (2) Biochemical Assay Reagents (1) Drug Intermediate (1) Drug Metabolite (1) NO Synthase (1) Parasite (2) PKC (1) Potassium Channel (1) Sodium Channel (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1)

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-100593

Spiramycin 1 篇文献验证 Rovamycin	Bacterial Parasite Antibiotic	Infection
螺旋霉素 Spiramycin (Rovamycin) 是由链霉菌 (Streptomyces ambofaciens) 产生的大环内酯抗生素，具有抗细菌和抗弓形虫的作用，并具有抗寄生虫作用。Spiramycin (Rovamycin) 由 16 个内酯环组成，其上附着三种糖 (mycaminose，forosamine 和 mycarose)。

HY-12545

Brevetoxin-3 1 篇文献验证 PbTx-3	Sodium Channel	Inflammation/Immunology
Brevetoxin-3 (PbTx-3) 是一种有效的变构电压门控 Na⁺ 通道 (Na⁺ channels) 激活剂，具有多个活性中心 (A 环内酯，R 侧链的 C-42)。Brevetoxin-3 (PbTx-3) 对电压敏感的 Na⁺ 通道的位点 5 具有高亲和力，抑制 Na⁺ 通道的失活并延长这些通道的平均打开时间。Brevetoxin-3 (PbTx-3) 可导致气道高反应性 (AHR) 延长和肺部炎症。

HY-138166

Rosuvastatin lactone	Drug Metabolite NO Synthase Potassium Channel	Cardiovascular Disease
Rosuvastatin lactone 是 Rosuvastatin (HY-17504A) (一种他汀类降脂剂；HMG-CoA 抑制剂) 的代谢物。Rosuvastatin lactone 在大鼠主动脉环中表现出不依赖内皮且不依赖 HMG-CoA 还原酶的舒张活性，其舒张效应是由位于血管平滑肌中的诱导型一氧化氮合酶 (iNOS) 产生的 NO 以及钾离子通道 (Potassium Channel) 的激活共同介导的。Rosuvastatin lactone 本身不具有降血脂作用。

HY-N8810

Platycoside M1	Others	Others
Platycoside M1 是一种 A 环内酯三萜皂苷，可以从桔梗 (Platycodon grandiflorum) 的根中分离出来。桔梗苷类是桔梗的主要活性成分，具有多种药理活性。

HY-108603

Bryostatin 2 (+)-Bryostatin 2	PKC	Cancer
Bryostatin 2 ((+)-Bryostatin 2) 是一种 20 元环内酯，存在于 Bryozoan Eugufa neritina L 中。Bryostatin 2 具有研究 P-388 淋巴细胞白血病的潜力。

HY-W747907

4-Pyridoxolactone β-Pyracin	Others	Others
4-Pyridoxolactone (β-Pyracin) 是维生素 B6 降解途径 I 中的关键底物，主要参与土壤微生物介导的维生素 B6 代谢过程。4-Pyridoxolactone 作为 4-吡哆酸内酯酶的特异性底物，通过该酶催化的锌依赖性内酯环水解反应生成 4-吡哆酸。

HY-119392

16-Hexadecanolide	Biochemical Assay Reagents	Others
16-十六内酯 16-Hexadecanolide 是一种内酯，常应用于开环聚合反应，能够以较高的聚合速率被酶催化为聚合物。

HY-100593A

Spiramycin (hexanedioate) Rovamycin (hexanedioate)	Parasite Antibiotic Bacterial	Infection
Spiramycin hexanedioate (Rovamycin) 是由链霉菌 (Streptomyces ambofaciens) 产生的大环内酯抗生素，具有抗细菌和抗弓形虫的作用，并具有抗寄生虫作用。Spiramycin hexanedioate (Rovamycin) 由 16 个内酯环组成，其上附着三种糖 (mycaminose，forosamine 和 mycarose)。

HY-135755

δ-Lactone	Drug Intermediate	Others
δ-Lactone，一种 A 环降解产物，也是 Estrone (HY-B0234)、Estradiol (HY-B0141) 及其衍生物合成的重要中间体。

HY-N18879

Divinorin F	Others	Others
Divinorin F 是一种 Divinatorin 型 neo-clerodane diterpene。Divinorin F 可从 Salvia divinorum 中分离。

Spiramycin 1 篇文献验证 Rovamycin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Anti-parasitic Disease Research Antibacterial Disease Research Fields Source Classification	Bacterial Parasite Antibiotic
螺旋霉素 Spiramycin (Rovamycin) 是由链霉菌 (Streptomyces ambofaciens) 产生的大环内酯抗生素，具有抗细菌和抗弓形虫的作用，并具有抗寄生虫作用。Spiramycin (Rovamycin) 由 16 个内酯环组成，其上附着三种糖 (mycaminose，forosamine 和 mycarose)。

Brevetoxin-3 1 篇文献验证 PbTx-3	Natural Products other families Classification of Application Fields Plants Disease Research Fields Inflammation/Immunology Source Classification	Sodium Channel
Brevetoxin-3 (PbTx-3) 是一种有效的变构电压门控 Na⁺ 通道 (Na⁺ channels) 激活剂，具有多个活性中心 (A 环内酯，R 侧链的 C-42)。Brevetoxin-3 (PbTx-3) 对电压敏感的 Na⁺ 通道的位点 5 具有高亲和力，抑制 Na⁺ 通道的失活并延长这些通道的平均打开时间。Brevetoxin-3 (PbTx-3) 可导致气道高反应性 (AHR) 延长和肺部炎症。

4-Pyridoxolactone β-Pyracin	Structural Classification Natural Products Endogenous metabolite Source Classification	Others
4-Pyridoxolactone (β-Pyracin) 是维生素 B6 降解途径 I 中的关键底物，主要参与土壤微生物介导的维生素 B6 代谢过程。4-Pyridoxolactone 作为 4-吡哆酸内酯酶的特异性底物，通过该酶催化的锌依赖性内酯环水解反应生成 4-吡哆酸。

Divinorin F	Structural Classification Terpenoids Labiatae Encelia stenophylla Greene Diterpenoids Plants Source Classification	Others
Divinorin F 是一种 Divinatorin 型 neo-clerodane diterpene。Divinorin F 可从 Salvia divinorum 中分离。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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