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rRNA substrate

" in MCE Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (2) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Mitosis (1)
By Research Areas:	Cancer (2)
Oligonucleotides:	核苷酸类似物 (1)

抑制剂 & 激动剂

天然产物

寡核苷酸

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-113225

Guanosine triphosphate GTP	Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis	Cancer
Guanosine triphosphate (GTP) 是一种关键的核苷酸和细胞代谢调控因子。Guanosine triphosphate 通过结合 RNA 聚合酶 I 及 GPN 蛋白 (GPN1/3) 促进核糖体 DNA 定位、前 rRNA 转录和核糖体生物发生。Guanosine triphosphate 将 MYC 依赖的核糖体生成与核苷酸充足性相关联，充当支持蛋白质合成、DNA/RNA 合成及细胞信号传导的代谢闸门，同时也参与胰腺 β 细胞生理活动并作为活性氧的氧化底物。在 MYC 高表达的小细胞肺癌中，Guanosine triphosphate 通过 IMPDH 驱动的合成途径发生积累，进而影响细胞凋亡和有丝分裂过程。Guanosine triphosphate 用于研究小细胞肺癌、肝母细胞瘤及细胞代谢等。

HY-135189

6-Aminophenanthridine	Others	Others
6-Aminophenanthridine 抑制核糖体 (PFAR) 的蛋白质折叠活性。6-Aminophenanthridine 竞争性地阻断蛋白质底物与 rRNA 的结合，从而抑制 PFAR。

HY-E71201

16S rRNA Pseudouridine516 synthase	Biochemical Assay Reagents	Others
16S rRNA Pseudouridine516 synthase (EC 5.4.99.19) 特异性识别 16S rRNA 中的尿苷 516。体外实验表明，该酶不修饰游离的 16S rRNA。其优先底物是与 30S 核糖体蛋白结合的 16S rRNA 5'末端片段。

HY-E71200M

16S rRNA (guanine966-N2)-Methyltransferase	Biochemical Assay Reagents	Others
16S rRNA (guanine966-N2)-Methyltransferase (EC 2.1.1.171) 在体外能高效甲基化组装好的 30S 亚基的鸟嘌呤 966。不含蛋白质的 16S rRNA 不是 RsmD 的底物。该酶特异性地甲基化 16S rRNA 中鸟嘌呤 966 的 N2 位点。

HY-181064

FWG-33B	Epigenetic Reader Domain	Cancer
FWG-33B 是TRMT112:METTL5复合物的激活剂，其 IC₅₀ 值为 0.47 μM。FWG-33B 可用于乳腺癌、肝细胞癌、鼻咽癌的相关研究。

Guanosine triphosphate GTP	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis
Guanosine triphosphate (GTP) 是一种关键的核苷酸和细胞代谢调控因子。Guanosine triphosphate 通过结合 RNA 聚合酶 I 及 GPN 蛋白 (GPN1/3) 促进核糖体 DNA 定位、前 rRNA 转录和核糖体生物发生。Guanosine triphosphate 将 MYC 依赖的核糖体生成与核苷酸充足性相关联，充当支持蛋白质合成、DNA/RNA 合成及细胞信号传导的代谢闸门，同时也参与胰腺 β 细胞生理活动并作为活性氧的氧化底物。在 MYC 高表达的小细胞肺癌中，Guanosine triphosphate 通过 IMPDH 驱动的合成途径发生积累，进而影响细胞凋亡和有丝分裂过程。Guanosine triphosphate 用于研究小细胞肺癌、肝母细胞瘤及细胞代谢等。

Cat. No.	Product Name		Classification

HY-113225

Guanosine triphosphate GTP		核苷酸类似物
Guanosine triphosphate (GTP) 是一种关键的核苷酸和细胞代谢调控因子。Guanosine triphosphate 通过结合 RNA 聚合酶 I 及 GPN 蛋白 (GPN1/3) 促进核糖体 DNA 定位、前 rRNA 转录和核糖体生物发生。Guanosine triphosphate 将 MYC 依赖的核糖体生成与核苷酸充足性相关联，充当支持蛋白质合成、DNA/RNA 合成及细胞信号传导的代谢闸门，同时也参与胰腺 β 细胞生理活动并作为活性氧的氧化底物。在 MYC 高表达的小细胞肺癌中，Guanosine triphosphate 通过 IMPDH 驱动的合成途径发生积累，进而影响细胞凋亡和有丝分裂过程。Guanosine triphosphate 用于研究小细胞肺癌、肝母细胞瘤及细胞代谢等。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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rRNA substrate

抑制剂 & 激动剂

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寡核苷酸

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