2. Apoptosis
  3. Apoptosis
  4. Selenodiglutathione

Selenodiglutathione (GSSeSG) 是一种硒代三硫化物，也是结合了两个谷胱甘肽基团的主要硒代谢物。Selenodiglutathione 可诱导 DNA 损伤、碱基氧化、链断裂、细胞凋亡。Selenodiglutathione 可通过优先被细胞摄取并提升细胞内硒水平，对乳腺癌细胞表现出细胞毒性。Selenodiglutathione 可用于乳腺癌的相关研究。

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Selenodiglutathione

Selenodiglutathione Chemical Structure

CAS No. : 33944-90-0

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Selenodiglutathione 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Selenodiglutathione (GSSeSG) is a selenotrisulfide and the major selenium metabolite conjugated with two glutathione moieties. Selenodiglutathione induces DNA damage, base oxidation, strand breaks, apoptosis. Selenodiglutathione exhibits cytotoxicity against breast cancer cells via preferential cellular uptake and elevation of intracellular selenium levels. Selenodiglutathione is applicable to research related to breast cancer[1].

体外研究
(In Vitro)

Selenodiglutathione (1-10 μM; 24 h) 可降低 MCF-7 细胞的存活率，在浓度 ≥5 μM 时细胞存活率几乎完全丧失[1]。
Selenodiglutathione (5 μM; 24 h) 可诱导 MCF-7 细胞发生细胞凋亡[1]。
Selenodiglutathione (5-10 μM; 3 h) 可使 MCF-7 细胞内的硒水平分别升高约 20 倍和约 70 倍[1]。
Selenodiglutathione (1-10 μM; 3 h) 可诱导 MCF-7 细胞发生基因组 DNA 损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Selenodiglutathione 相关抗体:

Cell Viability Assay[1]

Cell Line: human breast cancer MCF-7 cells
Concentration: 1, 3, 5, 10 μM
Incubation Time: 24 h
Result: Reduced cell viability at 3 μM.
Caused near-complete viability loss at concentrations ≥5 μM.

Apoptosis Analysis[1]

Cell Line: human breast cancer MCF-7 cells
Concentration: 3 μM; 5 μM
Incubation Time: 24 h
Result: Induced apoptosis-dependent and apoptosis-independent cell death at 5 μM.
Did not increase apoptotic signals at 3 μM.
分子量

691.59

Formula

C20H32N6O12S2Se
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Selenodiglutathione 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selenodiglutathione33944-90-0GSSeSGApoptosisreactive oxygen speciesnecrosisapoptosisbreast cancer cellsoxidative DNA damagestrand fragmentationbase oxidationDNA strand breaksMCF-7 cellsintracellular thiolsInhibitorinhibitorinhibit

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