2. Membrane Transporter/Ion Channel Apoptosis Immunology/Inflammation
  3. Potassium Channel TNF Receptor Interleukin Related
  4. Siaresinolic acid

Siaresinolic acid 是一种被发现存在于 Sabicea grisea 叶片中的化合物。Siaresinolic acid 具有镇痛和抗炎活性。Siaresinolic acid 可通过 ATP 依赖性钾通道减少伤害性行为，抑制白细胞浸润、血浆渗出以及促炎介质 (TNF-α, IL-1β) 的产生。Siaresinolic acid 不会对小鼠巨噬细胞产生细胞毒性，大剂量下也不会改变自发活动。Siaresinolic acid 可用于胸膜炎和疼痛相关研究。

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Siaresinolic acid

Siaresinolic acid Chemical Structure

CAS No. : 511-77-3

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Siaresinolic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Siaresinolic acid is a compound found in the leaves of Sabicea grisea. Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel, inhibits leukocyte influx, plasma leakage, and proinflammatory mediator (TNF-α, IL-1β) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain[1].

IC50 & Target[1]

IL-1β

 

体外研究
(In Vitro)

Siaresinolic acid (1-200 μg/mL; 24 h) 对小鼠腹腔巨噬细无细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Siaresinolic acid 相关抗体:
体内研究
(In Vivo)

Siaresinolic acid (0.1-10 mg/kg；腹腔注射；醋酸注射前 1 小时) 在 Acetic acid (HY-Y0319) 诱导的扭体模型中产生剂量依赖性的外周镇痛作用，在 10 mg/kg 剂量下的最大抑制率为 70.9%[1]。
Siaresinolic acid (1 mg/kg；腹腔注射；福尔马林注射前 1 小时) 可选择性抑制小鼠福尔马林诱导伤害感受的炎症期[1]。
Siaresinolic acid (0.01-1 mg/kg；腹腔注射；Carrageenan 注射前 1 小时) 可剂量依赖性地抑制 Carrageenan (HY-125474) 诱导胸膜炎模型中的急性炎症反应，其中 1 mg/kg 剂量对关键促炎介质的抑制率超过 82%[1]。
Siaresinolic acid (1 mg/kg；腹腔注射) 在小鼠热板试验中不会产生中枢镇痛作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acetic acid-induced Swiss mice (male, 18-22 g)[1]
Dosage: 0.01 mg/kg; 0.1 mg/kg; 1 mg/kg; 10 mg/kg
Administration: I.p.; 1 hour before acetic acid injection
Result: Produced no alteration in nociceptive behavior at 0.01 mg/kg.
Reduced the number of abdominal writhes by 42.3% at 0.1 mg/kg.
Reduced the number of abdominal writhes by 58.2% at 1 mg/kg.
Reduced the number of abdominal writhes by 70.9% at 10 mg/kg.
Had its antinociceptive effect fully blocked by pretreatment with Glibenclamide (HY-15206) at 1 mg/kg.
Animal Model: Carrageenan-induced Swiss mice (male, 18-22 g)[1]
Dosage: 0.01 mg/kg; 0.1 mg/kg; 1 mg/kg
Administration: I.p.; 1 hour before carrageenan injection
Result: Significantly reduced total leukocyte count, neutrophil count, and plasma leakage at all tested doses.
Left mononuclear cell count unaffected at all tested doses.
Reduced TNF-α levels by 82.3% at 1 mg/kg.
Reduced IL-1β levels by 95.7% at 1 mg/kg.
Reduced CXCL1 levels by 89.3% at 1 mg/kg.
分子量

472.70

Formula

C30H48O4
CAS 号
中文名称

暹罗树脂酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Siaresinolic acid 相关分类

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Keywords:

Siaresinolic acid511-77-3暹罗树脂酸Potassium ChannelTNF ReceptorInterleukin RelatedKcsATumor Necrosis Factor ReceptorTNFRILacetic acidmurine macrophagesleukocyteantinociceptiveformalinnociceptioncarrageenanpleurisyanti-inflammatoryInhibitorinhibitorinhibit

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