2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis
  4. Sideromycin 7

Sideromycin 7 是一种抗菌 (antibacterial) 剂。Sideromycin 7 可与柠檬酸铋形成 7-Bi3+ 配位复合物，发挥三重抗菌作用机制：直接结合 DNA 以诱导损伤并阻断复制，抑制 KdpC 的合成从而阻断 KdpFABC 介导的钾离子转运，以及抑制 ATP 生成。Sideromycin 7 对耐 Ciprofloxacin (HY-B0356) 的铜绿假单胞菌菌株表现出强效抗菌活性。Sideromycin 7 对铜绿假单胞菌具有抗生物膜活性。Sideromycin 7 可用于耐环丙沙星铜绿假单胞菌感染的相关研究。

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Sideromycin 7

Sideromycin 7 Chemical Structure

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Sideromycin 7 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sideromycin 7 is an antibacterial agent. Sideromycin 7 forms a 7-Bi3+ coordination complex with bismuth citrate, exerting a three-pronged antibacterial mode of action: direct DNA binding to induce damage and arrest replication, suppression of KdpC synthesis to block KdpFABC-mediated potas-sium transport, and inhibition of ATP production. Sideromycin 7 exhibits potent antibacterial activity against Ciprofloxacin (HY-B0356)-resistant Pseudomonas aeruginosa strains. Sideromycin 7 exerts antibiofilm activity against Pseudomonas aeruginosa. Sideromycin 7 can be used for the research of ciprofloxacin-resistant Pseudomonas aeruginosa infection[1].

体外研究
(In Vitro)

Sideromycin 7 与枸橼酸铋具有协同作用，对 Ciprofloxacin (HY-B0356) 耐药铜绿假单胞菌菌株表现出强效抗菌活性，其 MIC 较传统喹诺酮类抗生素低 3.2 至 21 倍[1]。
Sideromycin 7 (联合枸橼酸铋；连续传代 18 天) 在体外连续传代 18 天后，未诱导 Pseudomonas aeruginosa 859 或 7034 产生耐药性[1]。
Sideromycin 7 (联合枸橼酸铋；24 h) 可显著抑制 Pseudomonas aeruginosa 541 的生物膜形成，抑制率达 78%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sideromycin 7 相关抗体:
体内研究
(In Vivo)

Sideromycin 7 (8 mg/kg；原位注射；每日 1 次；连续 3 天) 可降低皮下小鼠感染模型中 P. aeruginosa 生物膜的细菌载量并促进伤口愈合[1]。
Sideromycin 7 (2-32 mg/kg；腹腔注射；共给药 2 次) 可降低中性粒细胞减少小鼠肺部感染模型中的细菌载量与肺部炎症[1]。
Sideromycin 7 (32 mg/kg；腹腔注射；每日 1 次；连续 28 天) 在小鼠体内耐受性良好，未观察到毒性反应或肠道菌群紊乱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 4-6 weeks old, 18-20 g, subcutaneous implantation of PDMS sheets precoated with P. aeruginosa 7034 biofilms)[1]
Dosage: 8 mg/kg
Administration: in situ injection; once daily; 3 days
Result: Reduced log10 CFU/mL of bacterial burden on PDMS sheets compared to vehicle control.
Improved wound healing with reduced visible inflammation compared to vehicle control.
Decreased necrotic areas and inflammatory infiltrates in skin and muscle tissue relative to vehicle control.
Animal Model: SPF ICR (female, 6 weeks old, 20-22 g, cyclophosphamide-induced neutropenic, intranasal inoculation with P. aeruginosa 535 and 541)[1]
Dosage: 2, 5, 8 32 mg/kg
Administration: intraperitoneal injection; two doses total (2 hours and 12 hours post-infection)
Result: Reduced log10 CFU/g of lung tissue compared to vehicle control for P.
aeruginosa 541 at 5 mg/kg, 8 mg/kg, or 32 mg/kg.
Reduced log10 CFU/g of lung tissue compared to vehicle control for P.
aeruginosa 535 at 8 mg/kg.
Reduced inflammatory cell infiltration in lung tissue relative to vehicle control.
分子量

573.61

Formula

C28H36FN5O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sideromycin 7 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sideromycin 7Sideromycin7Sideromycin-7BacterialDNA/RNA Synthesismurine modelsoxidative phosphorylation complexes IVoxidative phosphorylation complexes VPseudomonas aeruginosaKdpFABCgut microbiotapotassium transportKdpCciprofloxacin-resistant Pseudomonas aeruginosaDNA integrityInhibitorinhibitorinhibit

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