2. Others Neuronal Signaling
  3. Drug Derivative Cholinesterase (ChE)
  4. Stacofylline hydrochloride

Stacofylline hydrochloride (S 9977) 是一种 Xanthine (HY-W017389) 衍生物，是一种强效的 AChE 抑制剂，IC50 为 5-50 nM。Stacofylline 具有抗遗忘活性。

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Stacofylline hydrochloride

Stacofylline hydrochloride Chemical Structure

CAS No. : 138472-18-1

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Other Forms of Stacofylline hydrochloride:

Stacofylline hydrochloride 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Stacofylline hydrochloride (S 9977), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities[1][2].

IC50 & Target [1]

AChE

5-50 nM (IC50)

体外研究
(In Vitro)

Stacofylline hydrochloride 通过显着增加抑制性突触后电流 (IPSC) 的衰减时间常数 (Tc) 来增强胆碱能传递[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Stacofylline hydrochloride 相关抗体:
体内研究
(In Vivo)

Stacofylline hydrochloride (0.0312-0.5 mg/kg；口服) 在东莨菪碱、地西泮和电惊厥休克 (ECS) 小鼠模型中， 明显减轻了三种遗忘治疗引起的记忆缺陷[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

455.98

Formula

C20H34ClN7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Stacofylline hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stacofylline138472-18-1S 9977S9977S-9977Drug DerivativeCholinesterase (ChE)Drug derivativeInhibitorinhibitorinhibit

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目录号：
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