2. JAK/STAT Signaling Stem Cell/Wnt Metabolic Enzyme/Protease Apoptosis
  3. STAT MMP Apoptosis
  4. STAT3-IN-52

STAT3-IN-52 (Compound 9) 是一种选择性且具有口服活性的信号转导与转录激活因子 3 (STAT3) 抑制剂。STAT3-IN-52 与 STAT3 的 pY705 位点结合 (Ki 值为 440 nM)，可阻断 STAT3 的磷酸化和二聚化。STAT3-IN-52 对多种癌细胞表现出强烈的细胞毒性，例如乳腺癌 MDA-MB-231 (IC50 值为 0.7 μM)、髓母细胞瘤 UW426、胰腺癌 BKPC3 细胞。STAT3-IN-52 可诱导细胞凋亡 (apoptosis)，抑制 STAT3 的核转运和 DNA 结合活性，并下调 STAT3 靶基因 MMP9 的表达。STAT3-IN-52 可用于 STAT3 异常激活相关癌症的研究。

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STAT3-IN-52

STAT3-IN-52 Chemical Structure

CAS No. : 1556861-34-7

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规格 价格 是否有货 数量
5 mg ￥1598
1 - 2 周
10 mg ￥2550
1 - 2 周
50 mg   询价  
100 mg   询价  

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STAT3-IN-52 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-52 (Compound 9) is a selective and orally active signal transducer and activator of transcription 3 (STAT3) inhibitor. STAT3-IN-52 binds to the pY705 site of STAT3 (Ki = 440 nM), blocking the phosphorylation and dimerization of STAT3. STAT3-IN-52 shows strong cytotoxicity against various cancer cells, such as breast cancer MDA-MB-231 (IC50 = 0.7 μM), medulloblastoma UW426, pancreatic cancer BKPC3 cells. STAT3-IN-52 can induce cell apoptosis, inhibit the STAT3 nuclear transport and DNA binding activity and downregulate the expression of the STAT3 target gene MMP9. STAT3-IN-52 can be used for research related to STAT3 abnormal activation in cancer[1].

IC50 & Target[1]

STAT3

440 nM (Ki)

MMP-9

 

分子量

412.46

Formula

C20H20N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT3-IN-52 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-521556861-34-7STATMMPApoptosisMatrix metalloproteinasesInhibitorinhibitorinhibit

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