2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. SU0383

SU0383 是一种双重 MTH1 和 OGG1 抑制剂，其 IC50 值分别为 0.034 μM 和 0.49 μM。SU0383 在癌细胞中诱导细胞毒性，并增强肿瘤细胞对氧化应激的敏感性，对正常细胞中具有较低的毒性。SU0383 可用于癌症研究。

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SU0383

SU0383 Chemical Structure

CAS No. : 2598151-90-5

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SU0383 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SU0383 is a dual MTH1 and OGG1 inhibitor with IC50 values of 0.034 μM and 0.49 μM, respectively. SU0383 induces cytotoxicity in cancer cells and increases sensitivity of tumor cells to oxidative stress, and showing low toxicity in normal cells. SU0383 can be used for cancer research[1][2].

IC50 & Target[1]

MTH1

0.034 μM (IC50)

OGG1

0.49 μM (IC50)

体外研究
(In Vitro)

SU0383 (5-20 µM; 24-72 小时) 在 20 μM 时诱导 A549、H460 和 HCT116 细胞的细胞毒性[1]。
SU0383 (0.01-10 μM; 24 小时) 在 MCF-7 和 HeLa 细胞中表现出低毒性[2]。
SU0383 (10 μM; 16 小时) 增加了 MCF-7 肿瘤细胞对过氧化氢诱导的氧化应激的敏感性[2]。
SU0383 (10 μM) 与 MCF7 细胞中的天然 NUDT1 结合，并在 MCF7 裂解液中抑制天然 OGG1 活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SU0383 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, H460, HCT116
Concentration: 5-20 μM
Incubation Time: 24, 48, 72 h
Result: Induced noticeable cytotoxicity only at 20 μM in A549, H460, and HCT116 cells.
Showed no significant cytotoxicity at lower concentrations.

Cell Cytotoxicity Assay[2]

Cell Line: MCF-7 and HeLa human cell lines
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 24 h
Result: Displayed little or no measurable toxicity in MCF-7 and HeLa cells at concentrations up to 10 μM.
分子量

626.73

Formula

C33H34N6O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SU0383 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SU03832598151-90-5SU 0383SU-0383DNA/RNA Synthesislung adenocarcinomaMTH1OGG1tumor cellshuman cellsoxidative stressA549cancer cells8-oxo-dGoxidative DNA damageInhibitorinhibitorinhibit

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