2. Autophagy
  3. Autophagy
  4. Sucrose dilaurate

Sucrose dilaurate 是一种乳化剂、分散剂和稳定剂。Sucrose dilaurate 可减少经 UVB 照射的角质形成细胞释放 HMGB1。Sucrose dilaurate 能够抑制黑色素生成，降低胆红素水平。Sucrose dilaurate 可诱导人表皮角质形成细胞发生自噬 (autophagy)，从而降低羧甲基赖氨酸 (CML) 水平。Sucrose dilaurate 可减少衰老角质形成细胞分泌胰岛素样生长因子结合蛋白 3 (IGFBP3) 和神经生长因子 (NGF)。Sucrose dilaurate 可在化妆品、食品及制药行业中作为乳化剂、分散剂或稳定剂研究。

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Sucrose dilaurate

Sucrose dilaurate Chemical Structure

CAS No. : 25915-57-5

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Sucrose dilaurate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries[1][2][3][4].

体外研究
(In Vitro)

Sucrose dilaurate (作为 SDL 组合的组分，Sucrose dilaurate 和蔗糖二月桂酸酯的混合物，比例约为 6:4) 在无细胞体系中孵育时可显著降低胆红素水平，抑制过氧化氢诱导的人 tKC 角质形成细胞中胆红素的生成，降低 HaCaT 角质形成细胞内的胆红素水平，降低人皮肤切片中结合于皮肤的胆红素水平[2]。
Sucrose dilaurate (0.005%; 24 h) 可显著诱导新生儿人表皮角质形成细胞中的自噬体形成[3]。
Sucrose dilaurate (0.01%; 24 h) 可显著降低甘油醛糖基化的新生儿人表皮角质形成细胞中的 CML 水平[3]。
Sucrose dilaurate (0.001%; 72 h) 可显著抑制阿霉素诱导的衰老 HaCaT 角质形成细胞释放 IGFBP3 和 NGF[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sucrose dilaurate 相关抗体:

ELISA Assay[4]

Cell Line: doxorubicin-induced senescent HaCaT keratinocytes
Concentration: 0.001%
Incubation Time: 72 h
Result: Significantly suppressed the release of IGFBP3 from senescent HaCaT keratinocytes to levels similar to those released by normal keratinocytes.
Significantly suppressed the release of NGF from senescent HaCaT keratinocytes.
分子量

706.90

Formula

C36H66O13
CAS 号
中文名称

蔗糖二月桂酸酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sucrose dilaurate 相关分类

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Keywords:

Sucrose dilaurate25915-57-5蔗糖二月桂酸酯AutophagyemulsifierdispersantstabilizerHaCaT keratinocytesautophagosomeautophagyInhibitorinhibitorinhibit

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