2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. SYK-1106

SYK-1106 是一种强效的 δ 阿片受体 (DOR) 激动剂，其 EC50 为 89 pM，Ki 为 848 pM。SYK-1106 对 μ 和 κ 阿片受体具有选择性，其 Ki 分别为 9.54 和 2.45 nM。SYK-1106 可诱导剂量依赖性的类抗抑郁作用。SYK-1106 可用于抑郁症的研究。

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SYK-1106

SYK-1106 Chemical Structure

CAS No. : 2643940-93-4

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Other Forms of SYK-1106:

SYK-1106 相关抗体

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查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SYK-1106 is a potent delta-opioid receptor (DOR) agonist with an EC50 of 89 pM and a Ki of 848 pM. SYK-1106 is selective for μ and κ opioid receptors, with Ki values of 9.54 nM and 2.45 nM, respectively. SYK-1106 induces dose-dependent antidepressant-like effects. SYK-1106 can be used for the research of depression[1].

IC50 & Target[1]

δ Opioid Receptor/DOR

0.848 nM ()

μ Opioid Receptor/MOR

9.54 nM ()

κ Opioid Receptor/KOR

2.45 nM ()

体内研究
(In Vivo)

SYK-1106 (0.03-0.3 mg/kg; s.c.; 单次给药) 在小鼠强迫游泳试验中可产生剂量依赖性的、由 DOR 介导的类抗抑郁作用，在 0.1 mg/kg 剂量时开始显现显著活性，在 0.3 mg/kg 时达到最大效应，且不会改变自主活动能力或诱发惊厥[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 5 weeks old, acclimatized for ~7 days before experiments)[1]
Dosage: 0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg
Administration: s.c.; single dose (30 minutes before test sessions)
Result: Did not significantly alter immobility, swimming, or climbing counts at 0.03 mg/kg compared to vehicle.
Significantly reduced immobility counts and increased swimming counts at 0.1 mg/kg.
Produced the largest significant reduction in immobility counts, along with significant increases in swimming and climbing counts at 0.3 mg/kg.
Had antidepressant-like effects completely reversed by co-administration with NTI at 0.3 mg/kg.
Did not significantly alter locomotor activity at 0.3 mg/kg compared to vehicle.
Caused no convulsive effects at any tested dose.
分子量

447.61

Formula

C28H37N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SYK-1106 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SYK-11062643940-93-4SYK1106SYK 1106Opioid Receptormu opioid receptorsmouse forced-swim testCHO cellsdelta opioid receptorNTIdepressionhuman MORhuman DORkappa opioid receptorshuman KORInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-180212
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