2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Tan-931

Tan-931 是一种非竞争性的选择性芳香化酶 (aromatase) 抑制剂，对 aromatase 的 IC50 为 17.2 μM，对 human aromatase 的 Ki 为 40 μM，对 rat aromatase 的 IC50 为 162 μM。Tan-931 降低 PMSG (HY-N12634) 处理的雌性大鼠血浆雌二醇 -17β 水平以及卵巢和子宫重量。Tan-931 可用于雌激素依赖性转移性乳腺癌的研究。

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Tan-931

Tan-931 Chemical Structure

CAS No. : 127448-92-4

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Tan-931 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tan-931 is a non-competitive and selective inhibitor of aromatase , with an IC50 is 17.2 μM and a Ki of 40 μM for human aromatase, and an IC50 of 162 μM for rat aromatase. Tan-931 reduces plasma estradiol-17β level and weight of ovaries and uterus in PMSG (HY-N12634)-treated female rats. Tan-931 can be used for the research of estrogen-dependent metastatic breast cancer[1][2].

IC50 & Target[1][2]

Aromatase

17.2 μM (IC50)

Aromatase

40 μM (Ki)

体外研究
(In Vitro)

Tan-931 在微粒体测定中对芳香化酶的抑制作用较弱，其 IC50 为 17.2 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tan-931 相关抗体:
体内研究
(In Vivo)

Tan-931 (25-100 mg/kg；皮下注射；每日给药持续 4 天) 降低 PMSG 处理的雌性大鼠血浆雌二醇 17β 水平以及卵巢和子宫的重量 [1].
Tan-931 (100 mg/kg；皮下注射；每天给药 2 次持续 7 天) 未引起大鼠肾上腺肥大[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley (20-day-old) challenged with PMSG[1]
Dosage: 25, 50, 100 mg/kg
Administration: s.c.; daily for 4 days
Result: Reduced PMSG-induced increases in plasma estradiol-17β level and ovarian weight in a dose-dependent manner.
Reduced plasma estradiol-17β.
Slightly reduced uterine weight.
Reduced total and specific ovarian aromatase activity.
Animal Model: Sprague-Dawley (9-week-old male)[1]
Dosage: 100 mg/kg
Administration: s.c., twice daily for 7 days
Result: Did not induce adrenal hypertrophy.
Caused a significant increase in body weight.
Did not affect liver weight relative to controls.
分子量

302.24

Formula

C15H10O7
CAS 号
结构分类
初始来源

Penicillium funiculosum
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tan-931 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tan-931127448-92-4Tan931Tan 931Cytochrome P450CYPsgonadotropin-treated female ratsovariesestrogen-dependent metastatic breast canceruterusplasma estradiol 17βaromataseandrostenedionemale ratsSprague-Dawley ratsadrenal hypertrophyInhibitorinhibitorinhibit

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HY-180420
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