2. MAPK/ERK Pathway
  3. MAP3K
  4. TAO Kinase-IN-3

TAO Kinase-IN-3 是一种强效的泛 TAOK (Thousand-And-One Kinase) 抑制剂，能够特异性结合并抑制 TAOK1、TAOK2 和 TAOK3 的激酶活性 (Kd 分别为 <0.17 nM，0.34 nM，和 0.17 nM)。TAO Kinase-IN-3 可用于研究阿尔茨海默病、原发性 tau 蛋白病及相关综合征。此外，TAO Kinase-IN-3 也被广泛应用于癌症恶病质及其引发的肌肉萎缩机制研究。

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TAO Kinase-IN-3

TAO Kinase-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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TAO Kinase-IN-3 相关抗体

Top Publications Citing Use of Products

查看 MAP3K 亚型特异性产品:

查看所有亚型
MAP3K7/TAK1 MAP3K8/COT/Tpl2 MAP3K6/ASK2 MAP3K5/ASK1 MAP3K12/DLK/Pref-1 NIK/MAP3K14

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAO Kinase-IN-3 is a potent pan-TAOK (Thousand-And-One Kinase) inhibitor that specifically binds to and inhibits the kinase activities of TAOK1, TAOK2 and TAOK3 with Kd values of <0.17 nM, 0.34 nM, and 0.17 nM, respectively. TAO Kinase-IN-3 can be used to study Alzheimer's disease, primary tauopathies and related syndromes. In addition, TAO Kinase-IN-3 is also widely used in research on the mechanisms of cancer cachexia and the muscle atrophy it induces[1].

体外研究
(In Vitro)

TAO Kinase-IN-3 (compound 2) 可分别与人 HEK293 细胞中 TAOK1、TAOK2 和 TAOK3 结合，对应的 Kd 值分别为 <0.17 nM、0.34 nM 和<0.17 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TAO Kinase-IN-3 相关抗体:
分子量

445.90

Formula

C24H20ClN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAO Kinase-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAO Kinase-IN-3MAP3KMAP kinase kinase kinase, MEKK, MAPKKKcancer cachexia-associated muscle atrophysyndrome associated with an underlying primary tauopathyTAOK1primary tauopathyAlzheimer's diseasecancer cachexiaTAOK2TAOK3Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-181619
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