2. Neuronal Signaling
  3. Tau Protein
  4. Tau-aggregation-IN-5

Tau-aggregation-IN-5 可抑制 Tau 蛋白聚集 (EC50 = 0.31 μM)。Tau-aggregation-IN-5 以共价键结合 P4HB，并可激活轻度内质网应激。Tau-aggregation-IN-5 可用于研究阿尔茨海默病和皮克氏病等神经退行性疾病。

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Tau-aggregation-IN-5

Tau-aggregation-IN-5 Chemical Structure

CAS No. : 1283397-08-9

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Tau-aggregation-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tau-aggregation-IN-5 is a Tau-aggregation inhibitor (EC50 = 0.31 μM). Tau-aggregation-IN-5 targets P4HB covalently and activates mild ER stress. Tau-aggregation-IN-4 can be used for the study of neurodegenerative disorders such as Alzheimer’s and Pick’s diseases[1].

体外研究
(In Vitro)

Tau-aggregation-IN-5 (Compound 2a) (0.008-10 μM) 以剂量依赖的方式清除人诱导多能干细胞 (hiPSC) 来源神经元中的tau蛋白积累，EC50 为 190 nM，最大清除率超过 90 %[1]。
Tau-aggregation-IN-5 (3 μM，24 小时) 不影响 SH-SY5Y 细胞中非聚集 tau 蛋白的水平[1]。
Tau-aggregation-IN-5 (10 μM，6 小时) 导致 SH-SY5Y 细胞中 22,537 个转录本中 590 个基因的表达发生显著变化，包括 ERO1B、HSPA5 和 HERPUD1[1]。
Tau-aggregation-IN-5 (10 μM，2-6 小时) 显著上调 SH-SY5Y 细胞中 ERAD 相关蛋白 HERPUD1 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tau-aggregation-IN-5 相关抗体:
分子量

251.28

Formula

C15H13N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tau-aggregation-IN-5 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tau-aggregation-IN-51283397-08-9Tau ProteinChemoproteomicsNeurodegenerative DiseasePhenotypic ScreeningTarget identificationTauopathyInhibitorinhibitorinhibit

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