2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. Tyrosinase FGFR
  4. Tec-IN-14

Tec-IN-14 可阻断 Tec 激酶 与 FGF2 之间的相互作用，IC50 为 7.0 μM。Tec-IN-14 可抑制细胞中 FGF2 的非经典分泌。Tec-IN-14 可在细胞环境中抑制 FGF2 的酪氨酸磷酸化。Tec-IN-14 可用于癌症的相关研究。

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Tec-IN-14

Tec-IN-14 Chemical Structure

CAS No. : 852838-07-4

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Tec-IN-14 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tec-IN-14 blocks the interaction between Tec kinase and FGF2 with an IC50 of 7.0 μM. Tec-IN-14 inhibits the non-classical secretion of FGF2 in cells. Tec-IN-14 suppresses the tyrosine phosphorylation of FGF2 in a cellular environment. Tec-IN-14 is applicable to research related to cancer[1].

体外研究
(In Vitro)

Tec-IN-14 (compound 14) (50 μM) 可在表达 FGF2-GFP 的 CHO 细胞细胞中抑制 FGF2 的酪氨酸磷酸化[1]。
Tec-IN-14 (10-50 μM; 40 h) 可呈剂量依赖性抑制 CHO 细胞中 FGF2 的非经典分泌[1]。
Tec-IN-14 (10-50 μM; 72 h) 不会对 CHO 细胞的活力或增殖产生显著的多效性影响，仅会使增殖速率出现轻微降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tec-IN-14 相关抗体:

Western Blot Analysis[1]

Cell Line: CHO cells with Doxycycline (HY-N0565)-inducible FGF2-GFP expression
Concentration: 10, 25, and 50 μM
Incubation Time: 40 h (including 24 h pre-incubation and 16 h doxycycline-induced expression)
Result: Inhibited FGF2-GFP secretion to cell surfaces in a dose-dependent manner.
分子量

418.25

Formula

C18H16BrN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tec-IN-14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tec-IN-14852838-07-4TyrosinaseFGFRFibroblast growth factor receptortyrosine phosphorylationsmall cell lung cancerTec kinaseCHO cellsautophosphorylationFGF2Inhibitorinhibitorinhibit

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