2. Metabolic Enzyme/Protease Anti-infection Immunology/Inflammation Apoptosis
  3. Renin Bacterial Interleukin Related TNF Receptor
  4. Theasinensin C

Theasinensin C 是一种口服有效的肾素抑制剂和菌群调节剂，对肾素活性的 IC50 为 40.21 μM。Theasinensin C 可在肠道菌群中选择性富集嗜黏蛋白阿克曼菌 (Akkermansia muciniphila)，增强其介导的黏蛋白 PTS 结构域水解，驱动管腔谷氨酰胺与丝氨酸积累，并调控肠-肾-肝谷氨酰胺/丝氨酸代谢信号通路以促进肌酸生物合成。Theasinensin C 可改善认知功能、减少促炎细胞因子、缓解神经病理改变并恢复肠道屏障完整性。Theasinensin C 可用于高血压及高果糖饮食诱导的神经炎症相关研究。

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Theasinensin C

Theasinensin C Chemical Structure

CAS No. : 89013-69-4

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Theasinensin C 相关抗体

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  • 生物活性

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生物活性

Theasinensin C is an orally effective renin inhibitor and gut microbiota modulator, with an IC50 of 40.21 μM against renin activity. Theasinensin C selectively enriches Akkermansia muciniphila in the gut microbiota, enhances the Akkermansia muciniphila-mediated hydrolysis of the PTS domain of mucin, drives the accumulation of luminal glutamine and serine, and regulates the gut-kidney-liver glutamine/serine metabolic signaling pathway to promote creatine biosynthesis. Theasinensin C improves cognitive function, reduces pro-inflammatory cytokines, alleviates neuropathological changes and restores intestinal barrier integrity. Theasinensin C can be used in research related to hypertension and neuroinflammation induced by high-fructose diet[1][2].

体外研究
(In Vitro)

Theasinensin C (48 h) 可增强 Akkermansia muciniphila XJ 240720 介导的黏蛋白 PTS 结构域降解，使管腔 L-谷氨酰胺和 L-丝氨酸水平显著升高[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Theasinensin C 相关抗体:
体内研究
(In Vivo)

Theasinensin C (150 mg/kg；灌胃；每日；持续 8 周) 可通过改善认知功能、降低全身及中枢炎症标志物水平、恢复肠道屏障完整性，以及重构肠道菌群以富集 Akkermansia muciniphila 等有益菌，缓解雄性 C57BL/6J 小鼠中由 HFrD 诱导的神经炎症[3]。
Theasinensin C (150 mg/kg；灌胃；每日给药；持续 8 周) 可减轻高脂饮食 (HFrD) 诱导的经抗生素预处理的无菌雄性 C57BL/6J 小鼠神经炎症，改善认知功能并降低中枢炎症标志物水平；且与 Akkermansia muciniphila 来源的代谢物联合使用时，其疗效会增强[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (8-week-old male, SPF grade, HFrD-induced neuroinflammation)[3]
Dosage: 150 mg/kg/day
Administration: oral gavage; daily; 8 weeks
Result: Shortened escape latency in MWM training, increased percentage of distance and time spent in the target quadrant, and increased number of platform crossings compared to HFrD controls.
Decreased serum levels of LPS, TNF-α, and IL-6, and increased serum IL-10 levels compared to HFrD controls.
Reduced number of damaged neurons in the hippocampus and cortex; decreased mean fluorescence density of GFAP and IBA-1 in the hippocampus; downregulated hippocampal and cortical mRNA expression of Il-6, Tnf-α, Il-1β, Mcp-1, iNos, and Cox-2 compared to HFrD controls.
Alleviated colonic shortening, submucosal edema, inflammatory infiltration, crypt damage, and goblet cell loss; downregulated colonic mRNA expression of Tnf-α, Il-6, Il-1β, and Mcp-1; upregulated colonic mRNA expression of Zo-1, Occludin, Claudin-1, and Muc1 compared to HFrD controls.
Selectively enriched beneficial taxa; suppressed pro-inflammatory taxa including Desulfovibrio desulfuricans, Neisseria mucosa, Helicobacter hepaticus, and Ruminococcus gnavus compared to HFrD controls; restored HFrD-reduced levels of acetate, propionate, i-butyrate, n-butyrate, n-valerate, lactic acid, and total acids in colonic contents, and upregulated intestinal SCFA receptor genes Ffar2 and Ffar3.
Animal Model: C57BL/6J (8-week-old male, SPF grade, antibiotic-pretreated germ-free, HFrD-induced neuroinflammation)[3]
Dosage: 150 mg/kg/day
Administration: oral gavage; daily; 8 weeks
Result: Reduced escape latency in MWM training, increased percentage of distance and time spent in the target quadrant, and increased number of platform crossings compared to HFrD controls (efficacy was less than the combined metabolite group of theasinensin C and Akkermansia muciniphila, but greater than HFrD controls).
Reduced number of damaged neurons in the hippocampus and cortex; decreased mean fluorescence density of GFAP and IBA-1 in the hippocampus; downregulated hippocampal and cortical mRNA expression of Il-6, Tnf-α, Il-1β, Mcp-1, iNos, and Cox-2 compared to HFrD controls.
分子量

610.52

Formula

C30H26O14
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Theasinensin C 相关分类

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Keywords:

Theasinensin C89013-69-4ReninBacterialInterleukin RelatedTNF ReceptorILTumor Necrosis Factor ReceptorTNFRcreatine biosynthesisrenin-angiotensin systemAkkermansia muciniphilahigh-fructose diet-induced neuroinflammationmucin PTS domainserineC57BL/6J micehypertensionreninglutamineInhibitorinhibitorinhibit

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