2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage Epigenetics
  3. Glyoxalase (GLO) Apoptosis DNA/RNA Synthesis PARP
  4. TLSC702

TLSC702 是一种人乙二醛酶 I (hGLO I) 抑制剂，其 IC50 为 2.0 μM。TLSC702 可抑制人乙二醛酶 I 的活性，进而导致甲基乙二醛及其衍生的晚期糖基化终产物积累。TLSC702 可抑制肿瘤细胞增殖，诱导肿瘤细胞发生凋亡 (apoptosis) 形态学改变、核小体间 DNA 片段化以及 PARP 切割。TLSC702 可用于白血病、肺癌的相关研究。

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TLSC702

TLSC702 Chemical Structure

CAS No. : 748786-57-4

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TLSC702 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TLSC702 is a human glyoxalase I (hGLO I) inhibitor with an IC50 of 2.0 μM. TLSC702 inhibits the activity of human glyoxalase I, thereby leading to the accumulation of methylglyoxal and its derived advanced glycation end products. TLSC702 inhibits tumor cell proliferation, induces apoptotic morphological changes, internucleosomal DNA fragmentation and PARP cleavage in tumor cells. TLSC702 can be used in research related to leukemia and lung cancer[1].

体外研究
(In Vitro)

TLSC702 (24 h) 以剂量依赖方式抑制人髓系白血病 HL-60 细胞的增殖，其 EC50 约为 400 μM[1]。
TLSC702 (100-1000 μM; 24 h) 可呈剂量依赖性诱导人髓系白血病 HL-60 细胞发生凋亡，形态学改变、DNA 梯状条带形成和 PARP 切割可佐证这一结果，且在 1000 μM 浓度下还会出现坏死性细胞死亡[1]。
TLSC702 (24-72 h) 相较于 GLO I 低表达的人肺癌 NCI-H460 细胞，可优先抑制 GLO I 高表达的人肺癌 NCI-H522 细胞的增殖；其对 NCI-H522 细胞的抗增殖作用具有时间依赖性，对应的 EC50 值分别为 >300 μM (24 h)、202 μM (48 h) 和 145 μM (72 h)[1]。
TLSC702 (300 μM; 24-72 h) 可诱导人肺癌 NCI-H522 细胞中精氨酸嘧啶加合物的积累[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TLSC702 相关抗体:

Apoptosis Analysis[1]

Cell Line: human myeloid leukemia HL-60 cells
Concentration: 100, 300 and 1000 μM
Incubation Time: 24 h
Result: Induced dose-dependent apoptotic morphological changes, including apoptotic bodies at 300 and 1000 μM.
Induced characteristic apoptotic DNA ladder formation in a dose-dependent manner at 300 μM.
Detected dose-dependent cleavage of PARP across tested concentrations.
Detected necrotic cell death at 1000 μM.

Western Blot Analysis[1]

Cell Line: human lung cancer NCI-H522 cells
Concentration: 300 μM
Incubation Time: 24, 48, 72 h
Result: Induced accumulation of argpyrimidine adducts (methylglyoxal-derived advanced glycation end-products) in NCI-H522 cells.
分子量

325.38

Formula

C18H15NO3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TLSC702 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLSC702748786-57-4TLSC 702TLSC-702Glyoxalase (GLO)ApoptosisDNA/RNA SynthesisPARPpoly ADP ribose polymerasehuman myeloid leukemia HL-60 cellsleukemiahuman lung cancer NCI-H522 cellsmethylglyoxalapoptosisadvanced glycation end-productslung cancerhuman glyoxalase IPARP cleavagehuman lung cancer NCI-H460 cellsInhibitorinhibitorinhibit

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